This Is MS Multiple Sclerosis Knowledge & Support Community

Found this Tracking Down-- The Causes Of Multiple Sclerosis ---and am suprised noone posted it.
This may be start of something wonderful.

Tracking Down The Causes Of Multiple Sclerosis-Science Daily-Dated:June 25 2009.
I haven't seen it posted but I do miss alot.It may be here.

Article discusses NEW mouse model.

http://www.sciencedaily.com/releases/20 ... 133503.htm

Informative!

When the "auto immune" concept is presumed legitimate at the outset of any research than all roads lead to the mantra:

"All of these insights could provide the basis for the development of new approaches to the treatment of the disease" no matter how nonsensical the original presumption may be!

So I ask the question....what mechanism in your system is causing the T and B cells to start on their path of destruction. And why, in the examination of the brains of some dead MS patients, is no immune system activity found at all?

Harry

arthurherr wrote:Article discusses NEW mouse model.
http://www.sciencedaily.com/releases/20 ... 133503.htm

I was interested in the "new mouse" model. This is the link at the end of thne article:
http://jem.rupress.org/content/206/6/1303.abstract

hey the full text is available! (have not read it yet)
http://jem.rupress.org/content/206/6/1303.full

Why are they not using this mouse in research? cost? ease? predictability/repeat-ability or results?

I would love to see a study of a comparison of "mouse models" of MS where they compare the response of each mouse model (SJL/J, EAE, JC Virus, TMEV and any others) against each currently available treatment and them compared it to the actual response we get in the human population. Am I the only one who would want this? it seems like obvious check to do, unless you are a pharma that has developed a brilliant EAE cure.

there are so many "algias" and "oses" whose symptoms overlap, however much the AMA perfers stuffing each of them into their neatly-LIEbled compartmentalized areas.

Who says that, no thanks to our modern era, internal pathogens of MS'ers (and for that matter the general populace) aren't in a chronic state of stimulation & replication, due to the barrage of EMFs, and extreme citrus, sodium & onions hidden in so-called "health-foods" without letup?
...(not least of the EMFs, are phosphors of LCD/LED monitors & high-ghz processors - which is why PixelQi's epaper mode & Fit-PC2 are advisable.

Who says that some of the manifestations experienced by Electrosensitives & Fibromyalgics aren't also experienced by some MS'ers?

Like, what about peripheral neuropathy, & peripheral arterial disease?

And what about the fact that WOMEN in all of these LIEbled "algias" & "oses" predominate?
Doesn't that possibly point (at least partially) to narrower veins & arteries?

btw, another example of compartmentalization (vs. connecting the dots) is an article I just read about EDMT that's secreted by the Pineal Gland. I'm not even sure the Pineal is listed in medical lexicons. So the "official researchers" say that NDE's & OBE's are one thing, meditation something else, and schizophrenia in an altogether different category, whereas, according to the compiler of the article, they actually may all tie in with the EDMT secretion; the only difference being, that OBE's & meditation exit you completely into an alternate reality (temp. body paralysis), whereas schizo alternates between this reality & alternate (similar to phone reception fading in/out due to poor connection).

I'm glad I found this Thread because I had been wanting to write down my thoughts on the causes of MS for sometime after reading Siddhartha Mukherjee's amazing book "The Emperor of All Maladies...A Biography of Cancer". All of the quotes below are directly lifted from his book.

In his book Siddhartha outlines the difficulty cancer researchers had in relating that smoking was a cause of cancer. The first researcher to define what cause meant was the microbiologist Robert Koch in 1884. Koch required

"that the causal agent had to be present in diseased animals, it had to be isolated from diseased animals; and it had to be capable of transmitting the disease when introduced into a secondary host."

Cancer researchers could meet this test of "association, isolation, retransmission", so "Branford Hill, the eminence grise of epidemiology, proposed a solution to this impasse."

He argued that Epidemiologists could infer causality by using a list of nine criteria.

It was strong.
It was consistent.
It was specific.
It was temporal.
It possessed a "biological gradient.
It was plausible.
It was coherent; it was back by experimental evidence.
It behaved similarly in analogous situations.

"Cause is what cause does."

Ok so now that I have dumped that long list of what cause means in medicine I am going to try to prove that CCSVI is the cause of MS.

First using Koch's definition.

1.”that the causal agent had to be present in diseased animals”
Dr. Zamboni has found CCSVI present in 100% of folks with MS.

2.”it had to be isolated from diseased animals”
Dr. Fox found stenosis and vein blockages in all MS autopsies he did.

3.”and it had to be capable of transmitting the disease when introduced into a secondary host”
Dr. Putnam gave dogs MS by litigating their jugulars.

Now to prove CCSVI is the cause of MS by using Hill’s menu of criteria.

1. It was strong.

25% of people with clogged jugulars do not seem to have MS. 75% do.

2. It was consistent

People from Kuwait to Poland to Canada with MS seem to have stenosis in their veins

3. It was specific

Clogged veins in the neck lead to scars in the brain.

4. It was temporal

The longer one leaves clogged veins untreated the worse your MS will get.

5. It possessed a "biological gradient”

The sooner MS patients seem to clear their veins. The quicker their symptoms seem to improve.

6. It was plausible.

Constricted circulation is bad. Constricted circulation can cause scars. MS is a scar disease. People in Northern latitudes have constricted circulation and higher MS rates.

7. It was coherent; it was backed by experimental evidence

This body of evidence is growing.

8. It behaved similarly in analogous situations.

Budd-Chari in the liver shows similar cellular death and response through PTA. Biomarkers in the blood show folks with MS have problems with their endothelium.

In my next post I’ll go through the statistical method of power to disprove autoimmunity as the cause of MS.