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Anybody got any links on effects of p53.

PostPosted: Tue Jan 26, 2010 7:31 am
by Talisker
I was wondering if anybody has heard of any current research of the tp53 gene and the p53 protein and how it effects MSers.

PostPosted: Tue Jan 26, 2010 5:30 pm
by dignan
Maybe not be exactly what you're after, but this research might be in the ballpark:

"Inhibition of p53 Transcriptional Activity: A Potential Target for Future Development of Therapeutic Strategies for Primary Demyelination"

http://www.jneurosci.org/cgi/content/full/28/24/6118

PostPosted: Wed Jan 27, 2010 12:50 pm
by harry1
Now i'm a tad confused as this study seems to show that activated p53 causes MS and yet on the other hand those with higher levels of sun exposure have lower levels of MS and sunshine turns on p53 that tans the skin.

http://www.webmd.com/skin-problems-and-treatments/news/20070308/suntan-gene-may-explain-sun-worship

PostPosted: Wed Jan 27, 2010 3:18 pm
by notasperfectasyou
I like this topic and would like to see others here who are interested in the microbiological environment. Here's one I've been marking up for a while:

Culmsee, Carsten et al. 2003 Reciprocal Inhibition of p53 and Nuclear Factor-kB Transcriptional Activities Determines Cell Survival or Death in Neurons

Ken

PostPosted: Wed Jan 27, 2010 7:23 pm
by Talisker
Thanks dignan that like was interesting that p53 seemed to affect microglial behaviour.

Yes Harry I've read an abstract on research on how p53 affects tanning. This is for p53 proteins that are functioning normally and was probably researched as it was a newly discovered function of p53. Traditionally they're main role was viewed as checking cells as they developed and killing them if there was a fault. A more detailed and accurate definition is at wikipedia.

http://en.wikipedia.org/wiki/P53

Also notasperfectasyou thanks for the article.

Since I read that p53 is up regulated in MSers I've been trying to find out if there has been studies to see if the tp53 gene or the p53 protein of MSers are modified in some way. I know that HPV binds an E6 protein to p53 which inactivates it. What I've wondered is could p53 be changed to increase cell apoptosis.

PostPosted: Thu Jan 28, 2010 9:40 am
by harry1
Thanks for the wiki link about p53 Talisker !!!

harry

Re: p53

PostPosted: Thu Jan 28, 2010 10:03 pm
by NHE
I obtained this file a few years ago... Sometimes biology is a little more complex than we would like to think. There are many interactive players that affect p53. Moreover, this story is likely incomplete with more to be discovered.

Image

PostPosted: Fri Jan 29, 2010 5:13 am
by jimmylegs
love it NHE!!!