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I have been on LDN for about a month and a half now and my leg strength seems to be getting weaker. I started taking LDN the first of April at 1.5 mg. That was for a week, than I went to 3.0 mg for 3 weeks and now I am at 4.5 mg for the last 2 weeks. Should I stay at 4.5 mg for awhile and see what happens. I was taking amantadine for fatigue up until a week and a half ago but discovered that I did not need it any more. I guess that means the LDN is working for me in that regard but my weakening legs do concern me. If I stay at 4.5 mg and my legs continue to weaken will they stay that way or will they go back to where they were if I drop back to 3.0 mg. Or is it just progression because I do have ppms. Thank you for any comments.

dx 2008

I find anything more than 2.5mg is too much for me.

Hi. I tried LDN 4.5mg for six months and kept getting worse. I have since stopped and have stayed in this weakened state. It didn't work for me but I had to try. Good luck.