This Is MS Multiple Sclerosis Knowledge & Support Community

Hi,

I have been on LDN for the past two weeks. I started on 4.5mg/night and have had no real worrying symptoms apart from stiffness and a little increase in spacicity. Lucky, i know.

However, I do want to understand how LDN chemically/biologically causes the stiffness. Anyone know?

If a person without MS were to take LDN, would they also suffer from stiffness?

Thanks in advance.

ok, I found this reference at http://www.msrc.co.uk/downloads/LDNWEBINFOPACKmar05.doc

It has also become apparent that some patients, using the early supplies of LDN, have experienced increasing muscle stiffness and/or joint pain, after a few weeks of therapy.

This is believed to be due to an increased sensitivity to the lactose filler used in the initial supplies of the treatment at that time.

I am obviously now going to call my pharmacist. Ive never known myself to be lactose intolerant.

I also found the following, cant remember where...

It has been suggested that the leg stiffness is caused by the dead
microbes left in the body after the immune system starts working correctly
again

and also

Some of you only using 3.0mg LDN may be able to go up to 4.5mg LDN with the help of Milk Thistle. One of the pharmacists from the LDN website recommends it for the stiffness and I have heard a testimonial that it does help.

at http://ldn.proboards3.com/index.cgi?boa ... 1112660843

actually, came accross http://ldn.proboards3.com/index.cgi

I guess thats another suppliment to try...

I have checked with my compounder, and she was clear she used avicel (ie not lactose).

Also have bought some milk thistle. I'll let you know if it makes a difference.