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First dose

PostPosted: Thu Mar 08, 2012 7:15 pm
by astro
My doc has prescribed LDN, 4.5 mg, which I will be starting tomorrow. I know everyone reacts differently, but what is the range of things I can expect in the first few doses? Is it better to take in the morning or night time? (I would prefer to take in the morning so I can see how I react.)

Thanks!

Re: First dose

PostPosted: Mon Mar 12, 2012 7:33 am
by tzootsi
ALWAYS take LDN just before bed time. It works while you are sleeping. 4.5 is the strongest dose recommended - it may give you some morning spacticity.

Re: First dose

PostPosted: Thu May 10, 2012 3:30 pm
by FLJhawk
Maybe split a capsule in two for a few weeks before going to a full dose. You can do that by dissovling it in some water, maybe 20 ml or 2 oz or whatever. Pour 10 ml/ 1 oz into some juice and drink it before going to bed to get a 2.25 mg dose. You can gradually add more of the solution to your juice to increase the effective dose.

But, it should be ok to go directly with the 4.5 mg dose and see how you react. If you don't have major problems, you are good to go. If you do have issues, you can cut back to half and work your way up.

Re: First dose

PostPosted: Sat May 12, 2012 12:26 pm
by Barry
I started LDN @ 1.5mg 2 days ago. I'm thinking that after a week or 2 I'll go to 3mg and see what happens. Does that make any sense?

Re: First dose

PostPosted: Tue May 15, 2012 7:14 pm
by FLJhawk
Makes perfect sense to me, though I started at 2 mg, then to 3 after a few weeks, then to 4 after a month. I think some of the vivid dreams are dying now. Kind of a shame, as they were pretty interesting. No nightmares, just strange dreams that were actually entertaining.

Re: First dose

PostPosted: Fri May 18, 2012 10:34 am
by Barry
Dare I say that after a week the 'fog' has lifted noticeably. I think I'll bump up to 3 mg for a week and see what happens. :smile:

Re: First dose

PostPosted: Fri May 18, 2012 7:43 pm
by FLJhawk
Don't know if you should be able to see results from LDN this soon or not, but any improvement is good! Keep us informed.

Re: First dose

PostPosted: Sun May 20, 2012 7:41 am
by Barry
FLJhawk wrote:Don't know if you should be able to see results from LDN this soon or not, but any improvement is good! Keep us informed.


I've read anywhere from several days to several months to nothing happened. It just might be a freak of timing. I'm not about
to hang my hat on this but you're right - anything is better than nothing.

Re: First dose

PostPosted: Mon May 28, 2012 6:14 am
by Barry
So I'm a bit more than 2 weeks into this experiment. I'll be the first to admit that all of this might be a fluke of timing.

The fog is still there but has greatly reduced. My short term memory is much better. I'm more aware of the numbness in
my right arm and left leg. Balance is better - if I stand up and start going, it's about 2 steps behind me, so I stand up a wait
for a couple of seconds. I was on a ladder yesterday painting the garage door. No worries.

Last weekend I upped to 3 mg for 3 days and felt like crap. 1.5 mg seems to be my dose. I would be perfectly happy staying just
like right now. 6 months ago was no fun.

On the downside (?), time goes by much slower. That said, the house is spotless and the garden looks great.

Re: First dose

PostPosted: Mon May 28, 2012 4:13 pm
by FLJhawk
Some advise to keep upping the dose until you get to the magical 4.5 mg, even though the side effects might be uncomfortable for a while. But, if after a month you are still doing bad, then to drop back.

I saw, too, where someone said to skip a day every few weeks. I skipped two nights and today feel like #*$&. I really don't know if it is due to a withdrawl or just normal MS symptoms. I had been feeling fairly good over the last week, so I don't know.

And, I will continue to say, I don't really know if anyone knows that much about LDN on MS. There are people who say things about it but are just repeating what they heard somewhere (as I am doing), and no one may really know. We just have to experiment and try to draw our own conclusions.

Re: First dose

PostPosted: Tue Jun 12, 2012 8:01 am
by Barry
I'm a month into this LDN experiment. The brain fog has cleared up. A lot. Quite often I
find myself feeling almost old normal. My balance is much better in that I don't have to
think about going up and down stairs or hold onto the wall in the shower. The things
we take for granted, eh....

I find that sitting for any amount of time makes me feel foggier so I spend lots of
time in the garden or in my workshop.

A couple of weeks ago, I doubled the dose from 1.5mg to 3 and felt like crap – the fog
came back big time. So I went back to 1.5. I'm thinking about trying 4.5 over a couple of days just for fun.

What could go wrong? :)

Re: First dose

PostPosted: Wed Jun 20, 2012 7:14 am
by Barry
Well, I went with 4.5mg for 3 days. I didn't feel as bad as I did at 3mg but was much more foggy. I'm back to 1.5mg for the
time being. I'm not sure if it's smart to keep playing with the dose or not anymore?

Re: First dose

PostPosted: Sun Nov 12, 2017 2:10 pm
by Nicolaus9
How are you doing, Barry? Are you still on LDN?