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Tysabri rebound?
Posted: Sat Jul 20, 2013 6:32 am
by Ernst
There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?
Re: Tysabri rebound?
Posted: Sat Jul 20, 2013 9:33 am
by HarryZ
Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?
Tysabri is a drug that really plays with your immune system. It can effect MS patients in different ways if one decides to stop using it.
I don't believe they know enough about the mechanism of what happens to really have an answer as yet.
Harry
Re: Tysabri rebound?
Posted: Sat Jul 20, 2013 12:56 pm
by NHE
Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?
Try doing a search for IRIS which is also known as immune reconstitution inflammatory syndrome.
Re: Tysabri rebound?
Posted: Sat Jul 20, 2013 11:06 pm
by NHE
Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?
Here are some journal articles...
Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259335/
Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab therapy.
http://www.ncbi.nlm.nih.gov/pubmed/20937940
Immune reconstitution inflammatory syndrome in natalizumab-associated PML
http://www.neurology.org/content/77/11/1061.short
Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal
http://www.ncbi.nlm.nih.gov/pubmed/23100404
These are just a few examples. There are many more.