good results for Tysabri
Posted: Mon Sep 14, 2009 10:41 am
Biogen Idec and Elan Corporation, plc announced that data was presented at the 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) showing the potential of Tysabri (natalizumab) to redefine successful multiple sclerosis (MS) therapy. These data were from observational studies and retrospective analyses of the phase-III AFFIRM clinical trial.
Tysabri significantly improves measures of physical and cognitive disability using the Multiple Sclerosis Functional Composite (MSFC) in patients from the AFFIRM trial with baseline impairment; promoted regeneration or stabilization of damage to the myelin sheath, which can cause some of the symptoms seen in MS patients, as measured by advanced MRI technology; and shows improvement in quality of life as reported by patients.
"MS patients should expect more from an MS therapy and studies such as these demonstrate the potential for Tysabri to satisfy their expectations," said Michael Panzara, vice president and chief medical officer of neurology, Biogen Idec. "These data presented at ECTRIMS show that, for many MS patients, Tysabri may lead to improvement in a broad range of physical and cognitive symptoms."
"The strong efficacy profile demonstrated in clinical trials is enhanced further from these and other important Tysabri data presented at Ectrims," said Carlos Paya, president, Elan Corporation. "Tysabri is the first approved MS therapy with reported data suggesting some signs of the progression of MS can be stopped, whether measured by clinical, radiological or patient-reported measures."
"This data showing the ability of Tysabri to improve both physical and cognitive function represents a new paradigm for defining success in MS therapies," said Frederick E Munschauer, Irvin and Rosemary Smith professor, University of New York, Buffalo, New York.
Tysabri significantly improves measures of physical and cognitive disability using the Multiple Sclerosis Functional Composite (MSFC) in patients from the AFFIRM trial with baseline impairment; promoted regeneration or stabilization of damage to the myelin sheath, which can cause some of the symptoms seen in MS patients, as measured by advanced MRI technology; and shows improvement in quality of life as reported by patients.
"MS patients should expect more from an MS therapy and studies such as these demonstrate the potential for Tysabri to satisfy their expectations," said Michael Panzara, vice president and chief medical officer of neurology, Biogen Idec. "These data presented at ECTRIMS show that, for many MS patients, Tysabri may lead to improvement in a broad range of physical and cognitive symptoms."
"The strong efficacy profile demonstrated in clinical trials is enhanced further from these and other important Tysabri data presented at Ectrims," said Carlos Paya, president, Elan Corporation. "Tysabri is the first approved MS therapy with reported data suggesting some signs of the progression of MS can be stopped, whether measured by clinical, radiological or patient-reported measures."
"This data showing the ability of Tysabri to improve both physical and cognitive function represents a new paradigm for defining success in MS therapies," said Frederick E Munschauer, Irvin and Rosemary Smith professor, University of New York, Buffalo, New York.