Campath research articles
Posted: Mon Jan 05, 2009 2:30 am
First thing - happy New Year.
A belated Christmas present for Lyon and others.
Here is a link to Dr Alasdair Coles which give an overview of his work with Campath for MS. If you go down the page there is a section called Key publications. The first publication is the research article on the 3 year Phase II trial (CAMMS 223) - open the PDF file. Worth printing out as it is quite long with lots of tables / data. It may help those considering this as a possible treatment option - it sets out the benefits and some of the risks that have been seen (on the Campath and Rebif arms of the trial).
http://www.neuroscience.cam.ac.uk/direc ... php?Alcool
There are also links to other research articles on Campath - the earlier work before the formal trials. I was not on CAMMS 223 but a smaller project - 15 or so patients. I don't think Robin was part of CAMMS 223 but another project / trial. Like Robin, I think this treatment has proved extremely effective at stopping relapses / the progression of the disease for those with RR MS. The treatment is most effective earlier in the disease course - Dr Coles & co acknowledge that this present problems - the treatment comes with some risks yet those who will see the best results are those early in the disease course (with little if any permanent disability). I like Robin, have seen good recovery from some of the deficits left by my relapses and have had no relapses since my first infusion some 2.1 years ago.
Hope this is useful.
Ian
A belated Christmas present for Lyon and others.
Here is a link to Dr Alasdair Coles which give an overview of his work with Campath for MS. If you go down the page there is a section called Key publications. The first publication is the research article on the 3 year Phase II trial (CAMMS 223) - open the PDF file. Worth printing out as it is quite long with lots of tables / data. It may help those considering this as a possible treatment option - it sets out the benefits and some of the risks that have been seen (on the Campath and Rebif arms of the trial).
http://www.neuroscience.cam.ac.uk/direc ... php?Alcool
There are also links to other research articles on Campath - the earlier work before the formal trials. I was not on CAMMS 223 but a smaller project - 15 or so patients. I don't think Robin was part of CAMMS 223 but another project / trial. Like Robin, I think this treatment has proved extremely effective at stopping relapses / the progression of the disease for those with RR MS. The treatment is most effective earlier in the disease course - Dr Coles & co acknowledge that this present problems - the treatment comes with some risks yet those who will see the best results are those early in the disease course (with little if any permanent disability). I like Robin, have seen good recovery from some of the deficits left by my relapses and have had no relapses since my first infusion some 2.1 years ago.
Hope this is useful.
Ian