Bone Marrow Transplantation
Posted: Tue May 23, 2006 9:50 am
The following appeared on the Canada MS Society 'Ask an Expert' section. The answer was given by Dr Mark Freedman who is oversseing the project. It's good to see that those who have been througt it have not seen a recurrence of their MS and some have seen improvements.
Ian
Q :
A few months ago I saw a program on W-5 about MS patients who were undergoing bone marrow transplantation. Can you tell me anything more about how well they’re doing?
A :
Many are wondering about the status of the now 11 patients who have had the experimental treatment of chemotherapy to completely remove their immune system and replace it with a new one from their own blood stem cells. The rationale for this treatment was that since the exact nature of how the immune system has gone faulty in MS to start attacking the brain’s wire insulation (myelin) is still unknown, simply replacing the immune system with a new one should result in no further disease. So far, using all of our clinical and MRI surveillance techniques we have not been able to detect any evidence whatsoever of disease recurrence. What is more remarkable is that there appears to be some degree of recovery in various systems such as vision and motor function, but this has occurred several years after the transplant. Whether this change reflects the action of the stem cells used to replace the immune system (which can be stem cells for many systems including the brain) or the successful results of the body’s own ability to repair itself in the absence of ongoing disease remains to be worked out.
Ian
Q :
A few months ago I saw a program on W-5 about MS patients who were undergoing bone marrow transplantation. Can you tell me anything more about how well they’re doing?
A :
Many are wondering about the status of the now 11 patients who have had the experimental treatment of chemotherapy to completely remove their immune system and replace it with a new one from their own blood stem cells. The rationale for this treatment was that since the exact nature of how the immune system has gone faulty in MS to start attacking the brain’s wire insulation (myelin) is still unknown, simply replacing the immune system with a new one should result in no further disease. So far, using all of our clinical and MRI surveillance techniques we have not been able to detect any evidence whatsoever of disease recurrence. What is more remarkable is that there appears to be some degree of recovery in various systems such as vision and motor function, but this has occurred several years after the transplant. Whether this change reflects the action of the stem cells used to replace the immune system (which can be stem cells for many systems including the brain) or the successful results of the body’s own ability to repair itself in the absence of ongoing disease remains to be worked out.