This Is MS Multiple Sclerosis Knowledge & Support Community

Phase II Clinical Trial About to Begin using Lisinopril in MS:

http://www.transparencyls.com/?q=node/23

Very interesting. I was on lisinopril for HBP for years until I developed the dry cough. During that time, I had no MS symptoms or was even aware I had MS. Apx. 4 years ago, I switched to Benicar. All was well until apx. 15 months ago, when I had left-sided short-term paralysis & was diagnosed with MS via MRI, CAT scan. I went into remission after apx. 6 weeks, then apx. 5 months ago, I had a milder relapse with again left-sided weakness.
I would be interested to follow the lisinopril research.

In this study...

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity
http://www.pnas.org/content/106/35/14948.full.pdf

...the EAE mice were dosed with lisinopril at 10 mg/kg/day. That's about 60x the dosage normally given to a person with high blood pressure.

Is a dosage this high physiologically relevant?