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may well be! for ages iron has been the most common most widespread nutritional deficiency (setting aside the whole definition debate at least). i think product fortification with iron alone is potentially part of the problem where many people's lower zinc status is concerned.

Zyklon wrote:My temperature fluctuations maybe related to iron deficiency:

https://www.ncbi.nlm.nih.gov/pubmed/8989508

When I was on Avonex I had poor control of my body temperature especially while sleeping. I found it impossible to "sleep through the side effects" as the Avonex literature suggests. I instead started taking my shots around noon so I could better manage the side effects with ibuprofen while awake.

I walked today for 2 kilometers non-stop with plenty sunshine. Perfect sweating, perfect core temperature of 36.8 celcius. For some hours it was great 37.2-37.4 range. Very easy to manage, almost no symptoms. Then I had my dinner and vision blurred after a few bites. Temp was 37.7.

Rebif is all great for me. No temperature increase after injection, no flu-like symptoms day after, no sleep problems. My neurologist said Rebif maybe related with temperature fluctuations. I suspect iron deficiency and maybe Rebif.

New supplement plan:

30 minutes before breakfast 100 mg Iron (I hope my empty stomach will be ok, 1 glass of water)
After breakfast 4000 IU D3
After lunch 1000 mcg B12 (1 day off), 50 mg B-Complex
After midday snack 22 mg Zinc

i was cautioned to always take magnesium when supplementing d3, and that the timing was important. always take half the daily mag *with* d3, and the other half separately so that it can do its other several hundred jobs without being monopolized by d3 interactions. for years I had taken 4000 IU of d3 daily, with a little bit of magnesium usually taken simultaneously. that went badly for me ultimately :S

if you find the iron 'backs you up' a little, some types magnesium can help with that. the least absorbable forms such as mag oxide are renowned laxatives. not so great for absorption or retention when they 'go right through you', as it were.. the best forms for absorption, like magnesium glycinate, don't have the same laxative effect. so I would not expect those higher quality forms of magnesium to help with any constipation resulting from iron supplementation.

glad to hear you had a good day overall!

Low zinc or Prednisone (maybe both) is the new suspect for high blood sugar and meal-after body temperature increase. I will ask my neurologist if I can stop Prednisone.

Apart from urine color change, iron with empty stomach and zinc midday after snack without any problems. I have a small water spray, use it on my head and neck to lower my body temperature. Works great. It looks like I get fatigue and blurred vision with core temperatures above 37.7 Celsius. Before starting weight training, I want to resolve my core temperature issue.

Swanks diet sounds good for me, researching about it.

I searched for Vitamin D on youtube. Ludacris made me laugh alot (NSFW)

I am going to take an arrow in the knee now, Rebif time. I don't like leg injections, not much fat and little bit more pain, still no reason to skip.

will be interested to see the effects of your work on iron and zinc. good to hear no issues with those so far.
i look forward to seeing your copper result, especially with zinc also being low.

re swank, i only like diets if individuals' interpretation equates to meeting daily essential nutrient requirements for one's age, gender and activity level, in addition to influences of food combinations, meds, toxins, etc.

hope your injection went ok

Day 2 with iron and zinc. Massive energy increase, placebo or not I don't care

I had rebif kinda late yesterday and woke up midnight. Nothing major, slept again in 10 minutes.

Writing this after 3km high speed walk. Slacking increases my body temperature, walking decreases.

Blood sugar is better today. More tests on the way.

Lunch increased my body temperature to 37.7 from 36.9. Now I will do some more walking and see what will happen Result: Decreased to 37 with sweating.

My neurologist approved Prednisol reduction to 8mg (Down from 16mg, 4 days before planned date), 15 days more (no change).

I knock on wood for now, I wish everybody gets their inner peace and luck.

great news re energy and sugar.
hehe placebo effect from feeling better after restoring lab-verified depleted nutrients? maybe if your levels are still the exact same. doubt it!
re tests my fingers remain crossed for serum copper - makes typing a challenge ;)
glad you are feeling well.

I ate some whole wheat pasta with some sauce at dinner. My core temperature climbed to 37.9. ibuprofen did not work and it scared me alot.

Then with a "Dinggggg" sound, I decided to check my blood sugar (bg) level after 90 minutes. It was 190 mg/dl!!! I drank lots of water to get rid of bg. I did the test again after 120 minutes, 130 mg/dl felt much much better with core temperature of 37.1.

https://www.sciencedaily.com/releases/2 ... 141225.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797943/

Now I am almost sure my blood sugar and insulin balance is messed up and Prednisone is my number one suspect. I guess it is also linked with my cholesterol fail.

interesting. found the article abstract: http://diabetes.diabetesjournals.org/co ... 1/43.short

looks to be tied in closely with zinc as well:

Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc
http://www.jnutbio.com/article/S0955-2863(11%2900275-0/fulltext?cc=y=
"Serum zinc was significantly lower in diabetic patients compared to controls, and intracellular zinc showed the same tendency. Interestingly, type 2 diabetes patients treated with insulin displayed lower serum zinc compared to those not injecting insulin. In vitro analyses showed that insulin leads to an increase in intracellular zinc and that insulin signaling was enhanced by elevated intracellular zinc concentrations. In conclusion, we show that type 1 and type 2 diabetic patients suffer from zinc deficiency, and our results indicate that zinc supplementation may qualify as a potential treatment adjunct in type 2 diabetes by promoting insulin signaling, especially in zinc-deficient subjects."

i am basing this next info on recommendations from my own doc (based on a result a bit lower than yours, mind you):
as stated previously you should be okay to take up to 100 mg per day of zinc (divided doses with food to prevent nausea), for up to 1 month, while working to optimize levels. my own thoughts: should be especially okay since you are also taking iron.

i think you are correct re cholesterol as well - also as stated previously, zinc status influences lipid parameters.

wheat gluten creates a particular drain on zinc resources. something to be aware of as you reintroduce healthy carbs AND work towards zinc (and iron) repletion. wheat is also often fortified with iron but not zinc, potentially increasing its zinc-suppressing effect.

i used to react very strongly to wheat when zinc deficient. once you are topped up on this particular essential nutrient, your system should be better able to handle a gluten input like whole wheat pasta. in the meantime, you can employ strategies to reduce the influence of gluten in your food choices. eg breads made with sprouted flours, or sourdough. one thing that i think particularly fascinating is that wheat grown in zinc deficient soil has an altered gliadin to glutenin ratio. this change makes wheat more likely to create an undesirable reaction in people.

ways to achieve a solid daily essential zinc intake (with and without meat), both of which should be high enough to compensate for phytates (and possibly even high enough to make up for any contraceptive use by any ladies reading), while still being far from the daily upper limit:
interesting little exercise. not really that much more in the way of calories to achieve roughly equivalent veg zinc intake. now we just need to know what those daily intakes would deliver in serum levels, blood sugar, and lipid profile.

MS is sometimes funny

40 minutes before my body temp was 37.9. I did something extremely scientific, TOOK A SHOWER!!!

After shower my temp is still 36.5. I guess now I know how to reset my thermoregulator hahahaha

Tests today, feeling strong, gonna spend the day for myself, nothing else.

i imagine you'll have seen this case study

Periodic hyperthermia and abnormal circadian temperature rhythm in a patient with multiple sclerosis
http://journals.sagepub.com/doi/abs/10. ... 06ms1321cr

that kind of thing, predictably, makes me go looking for ways to support hypothalamus health.

first steps into the world of the hypothalamus:

Hypothalamic nutrient sensing in the control of energy homeostasis
http://journals.sagepub.com/doi/abs/10. ... 06ms1321cr

no time for any more right now. hope the testing goes well you have such rapid access to testing, i wonder if anyone has ever mentioned washing out to you?

Hey everyone. Its now been over a year since i first started feeling symptons and 6 months since diagnosis. I really struggle, i feel like I have become this person addicted to meds and booze. Every time I go without my meds, I end up feeling like a drug addict on a withdrawal. This then makes me feel like Im weak and depressed. I am so blessed to have such a supportive partner and my doctors are always on call. I hate how the weather affects my problems. I just dont know some times how to deal with everything. Has anyone else had the same issues at the start?

Hello Fazcat23.

I do whatever it takes to feel better including DMD, diet, supplements, exercise. After CIS my heat tolerance was low. I had problems with sweating. I pushed my limits sometimes, walked outside until I felt symptoms (weakness in legs, blurry vision) and stopped. One day I walked for 500 steps, another day 15000 steps. Pushing myself is my motivation, not the number. I accept the fact I will have problems with heat but it is not an excuse for me. Please consult your doctor. Everybody is different. It works for me but might be dangerous for you.

Now dealing with a Rebif side effect, fever. 38 degrees celcius max so far. Paracetamol works better for me than Ibuprofen. Shower, water spray, cold drinks.

I have some very mild symptoms that comes and goes in the last week. Today I had an MRI scan as a precaution and to see my 30 days progress. Good news is (knocking wood) I no longer have active lesions and no new lesions.

Another lesson for me, calcium blood serum test must be done with empty stomach. I missed my testing appointment, wasted 1 hour. Tomorrow again.