Low dose benadryl: An unknown treatment for MS
Posted: Sat Oct 12, 2013 6:21 am
I do not have MS. I have an acquired metabolic syndrome that is similar in symptom sets and is ultimately just a different manifestation of the same root cause.
I have just received the following feedback concerning a woman who has had MS for 18 years and thought you all might be interested:
I stay busy but i'm OK... Sorry i haven't kept in touch. I've been through some things that's kept me distracted from the benedryl and it's effects.
Vicki is not easily watched over. She's almost like a kid and has to be reminded over and over about doing anything consistently. I did notice a tremendous difference in her ability to focus on games of all kinds for hours after being on the antihistamine for a short time. To me it was a great difference. Before she could not get through any game without lots of help and would have double vision and confusion. Her energy level definitely improved and her level of interest.
She is very hard to monitor consistently. She's been busy with a new relationship and has been on a cruise that was great fun and has taken up smoking, drinking and late hours. she's still doing well but has forgotten to take the benedryl consistently and i'm constantly reminding her. I do think it had a good effect on her and she does too. She is trying to remember to take it but it's kind of hit and miss. She really needs a keeper. Don't we all.
Thanks for keeping up with us.
I responded:
Is this a test??
" She's been busy with a new relationship and has been on a cruise that was great fun and has taken up smoking, drinking and late hours."
I don't know what to say..other than...o..kay
chuckle...I guess that's good news
David
and her response:
All in all, she's definitely better. I probably shouldn't tell about her new habits but thought i should be straight about what's going on. she eats well and has started going to the MS wellness center for exercise. That is recent but i think that will help too. Gaining strength in her muscles will help her walk. She's trying to get stronger. Her mind seems stronger and she's more able to think straight. We just need the legs to get stronger and i think they will.
and My response:
Janice
I'm not judging...I can totally understand wanting to make up for all the pleasure lost due to a deteriorating condition....for 18 years. Actually that she CAN do these things is probably as good an indicator of the effectiveness of the LDB....
After all, being happier with the life you have is a very powerful thing...it gives you the will to do more than just survive.
wow that's good, I should write that down...lol
I would like to see you guys for lunch sometime soon, let me know
David
********************************************************************************************
And now some background, My exchange with Dr. Neil Lava...head of the MS clinic at Emory and an "EXPERT" on WEBMD
Mr. Staup,
Thank you for this information. I will look into it.
Neil Lava
From: David Staup [mailto:dstaup@sbcglobal.net]
Sent: Wednesday, August 08, 2012 4:10 PM
To: Lava, Neil
Subject: An unknown treatment for MS
Sir,
I found the following while investigating the benificial effects that 5 mg of benadryl every 4 to 6 hours has had on my condition (mitochondrial dysfunction).
"Institution: Stanford University
Summary
Researchers in Dr. Lawrence Steinman's laboratory at Stanford have developed a new strategy for treating or preventing autoimmune diseases with antihistamines. Using the EAE mouse model for multiple sclerosis (MS), the inventors have shown that the disease course and severity can be ameliorated with daily administration of antihistamine. This approach has the potential for treating MS with less side-effects and more convenient dosing than current therapeutic interventions.
Stage of Research
EAE mice treated daily with anti-histamine receptor 1 have decreased disease severity and delayed onset of the disease compared to controls. Also, treatment with antihistamine receptor 1 leads to significant changes in the serum IgG recognition of some healthy brain antigenic targets.
Advantage
Safe - antihistamines are established drugs with less severe side effects than current MS treatments e.g., interferon-beta, glatiramer acetate, high-dose IV immunoglobulins, monoclonal antibodies against a-4 integrin and steroids)
Convenient - oral administration is easier for patients costs to produce and store these compounds are lower than existing treatments
http://www.ctsaip.org/create-pdf.cfm?id=5893
I have been putting this info out on the web for a bit now, following is feedback from a diagnosed MS patient:
"My wife, who was diagnosed with MS in 2006, has been taking 5 mg of Benadryl every four hours for about three weeks now. She has experienced a dramatic increase in energy, an end to persistent conjunctivitis (redness of the eyes), and has not needed to apply her metronidazole cream for rosacea. She has also been able to stop taking Tramadol three times daily for back pain. The pain is still there, but it is more easily treated with the occasional NSAID or 5 mg of Valium. Here is a link to a patent application .pdf covering this treatment in greater detail. It is very technical, but it might be interesting to physicians and others with a scientific background. My wife takes slightly less than half a teaspoon of generic children's Benadryl (diphenhydramine) every four hours."
My personal experience and the following study lead me to believe many of the benificial effects of low dose benadryl stem from the fact that certain antihistamines in low doses inhibit apoptosis.
http://www.sciencedirect.com/science/ar ... 0261904498
specifically here:
"1. It is shown that a number of antihistamine drugs which prevent liver injury inhibit mitochondrial swelling at concentrations at which they do not affect electron transport or oxidative phosphorylation"
I saw you're postings on webmd and suspect you can do more than I with this info.
David Staup
I have just received the following feedback concerning a woman who has had MS for 18 years and thought you all might be interested:
I stay busy but i'm OK... Sorry i haven't kept in touch. I've been through some things that's kept me distracted from the benedryl and it's effects.
Vicki is not easily watched over. She's almost like a kid and has to be reminded over and over about doing anything consistently. I did notice a tremendous difference in her ability to focus on games of all kinds for hours after being on the antihistamine for a short time. To me it was a great difference. Before she could not get through any game without lots of help and would have double vision and confusion. Her energy level definitely improved and her level of interest.
She is very hard to monitor consistently. She's been busy with a new relationship and has been on a cruise that was great fun and has taken up smoking, drinking and late hours. she's still doing well but has forgotten to take the benedryl consistently and i'm constantly reminding her. I do think it had a good effect on her and she does too. She is trying to remember to take it but it's kind of hit and miss. She really needs a keeper. Don't we all.
Thanks for keeping up with us.
I responded:
Is this a test??
" She's been busy with a new relationship and has been on a cruise that was great fun and has taken up smoking, drinking and late hours."
I don't know what to say..other than...o..kay
chuckle...I guess that's good news
David
and her response:
All in all, she's definitely better. I probably shouldn't tell about her new habits but thought i should be straight about what's going on. she eats well and has started going to the MS wellness center for exercise. That is recent but i think that will help too. Gaining strength in her muscles will help her walk. She's trying to get stronger. Her mind seems stronger and she's more able to think straight. We just need the legs to get stronger and i think they will.
and My response:
Janice
I'm not judging...I can totally understand wanting to make up for all the pleasure lost due to a deteriorating condition....for 18 years. Actually that she CAN do these things is probably as good an indicator of the effectiveness of the LDB....
After all, being happier with the life you have is a very powerful thing...it gives you the will to do more than just survive.
wow that's good, I should write that down...lol
I would like to see you guys for lunch sometime soon, let me know
David
********************************************************************************************
And now some background, My exchange with Dr. Neil Lava...head of the MS clinic at Emory and an "EXPERT" on WEBMD
Mr. Staup,
Thank you for this information. I will look into it.
Neil Lava
From: David Staup [mailto:dstaup@sbcglobal.net]
Sent: Wednesday, August 08, 2012 4:10 PM
To: Lava, Neil
Subject: An unknown treatment for MS
Sir,
I found the following while investigating the benificial effects that 5 mg of benadryl every 4 to 6 hours has had on my condition (mitochondrial dysfunction).
"Institution: Stanford University
Summary
Researchers in Dr. Lawrence Steinman's laboratory at Stanford have developed a new strategy for treating or preventing autoimmune diseases with antihistamines. Using the EAE mouse model for multiple sclerosis (MS), the inventors have shown that the disease course and severity can be ameliorated with daily administration of antihistamine. This approach has the potential for treating MS with less side-effects and more convenient dosing than current therapeutic interventions.
Stage of Research
EAE mice treated daily with anti-histamine receptor 1 have decreased disease severity and delayed onset of the disease compared to controls. Also, treatment with antihistamine receptor 1 leads to significant changes in the serum IgG recognition of some healthy brain antigenic targets.
Advantage
Safe - antihistamines are established drugs with less severe side effects than current MS treatments e.g., interferon-beta, glatiramer acetate, high-dose IV immunoglobulins, monoclonal antibodies against a-4 integrin and steroids)
Convenient - oral administration is easier for patients costs to produce and store these compounds are lower than existing treatments
http://www.ctsaip.org/create-pdf.cfm?id=5893
I have been putting this info out on the web for a bit now, following is feedback from a diagnosed MS patient:
"My wife, who was diagnosed with MS in 2006, has been taking 5 mg of Benadryl every four hours for about three weeks now. She has experienced a dramatic increase in energy, an end to persistent conjunctivitis (redness of the eyes), and has not needed to apply her metronidazole cream for rosacea. She has also been able to stop taking Tramadol three times daily for back pain. The pain is still there, but it is more easily treated with the occasional NSAID or 5 mg of Valium. Here is a link to a patent application .pdf covering this treatment in greater detail. It is very technical, but it might be interesting to physicians and others with a scientific background. My wife takes slightly less than half a teaspoon of generic children's Benadryl (diphenhydramine) every four hours."
My personal experience and the following study lead me to believe many of the benificial effects of low dose benadryl stem from the fact that certain antihistamines in low doses inhibit apoptosis.
http://www.sciencedirect.com/science/ar ... 0261904498
specifically here:
"1. It is shown that a number of antihistamine drugs which prevent liver injury inhibit mitochondrial swelling at concentrations at which they do not affect electron transport or oxidative phosphorylation"
I saw you're postings on webmd and suspect you can do more than I with this info.
David Staup