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You have to like this statement:"Clearly such a rapid brain tissue loss is troublesome, because it may precede the accrual of disability in MS,6 and AHCST is a potentially lethal treatment associated with severe adverse effects".

Well yeah, in patients with SPMS with median EDSS 6.0..... Doctors keep saying the HSCT is best for RRMS, not the progressive forms. And if you keep reading the study you will see some interesting conclusion: "Although these observations need to be replicated by assessing MR imaging scans from other AHSCT trials of MS and need to be confirmed by longer periods of observation, it is plausible to suggest that the suppression of disease activity immediately after AHSCT might also beneficially affect the medium-term evolution of brain atrophy in aggressive phenotypes of MS."