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Three novel Multiple Sclerosis susceptibility loci identifie

PostPosted: Mon Jan 09, 2012 1:26 am

Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.

Nikolaos A. Patsopoulos, M.D., Ph.D., from the Brigham and Women's Hospital in Boston, and colleagues investigated MS susceptibility and explored the functional consequences of novel susceptibility loci.

They performed a one-stage meta-analysis of seven genome-wide association studies involving 2,529,394 unique single nucleotide polymorphisms obtained from 5,545 patients with MS and 12,153 controls. Quantitative trait analysis in peripheral blood mononuclear cells (PBMCs) of 228 individuals with demyelinating disease were used to explore RNA expression data....Read More - ... ageid/1347