This Is MS Multiple Sclerosis Knowledge & Support Community

This is fascinating, NHE.
I wanted hubby to stop his coffee drinking after dx, but out holistic doctor said not to worry, that caffeine had antioxidant properties.

In the past year, husband's had a few basal cell spots removed on his face, stomach and back (too much unprotected sun as a Californian kid) Maybe he should be bathing in coffee, too?

Makes me feel better about his espresso addiction-
AC

Cheerleader wrote:I wanted hubby to stop his coffee drinking after dx, but out holistic doctor said not to worry, that caffeine had antioxidant properties.

I don't know. It may be an antioxidant property of caffeine. However, these researchers seem to think that the inhibition of certain cancers has to do with caffeine's effect on DNA replication.

While at Harvard, he and his colleagues began focusing on a key protein governing DNA replication in all cells, known as ATR. They published a 2001 report in the Proceedings of the National Academy of Sciences suggesting ATR could be a good target for cancer therapy.

In the same journal about a year later, Nghiem read a report from Conney and his colleagues saying that applying caffeine to the skin of mice reduced skin cancer rates by 72 percent. The Rutgers team had by then discovered it was the caffeine, not some exotic herbal antioxidant, in the tea that fought cancer.

When Nghiem read Conney's report, he already knew caffeine "messes with" DNA replication and also chemically interacts with the ATR protein. So Nghiem called Conney up.

NHE

<shortened url>
I've upped my dose to 5000mg a day as I think this is helping quite a bit.

are you taking it as a single or divided dose? what else is in your tablets? mine have Bromelain (50mg) & Bioperine (3.5mg)

Bioperine increases absorption in most supplements as does with curcumin.
Almost all curcumin supps are the same regarding percentage curcuminoids but purity and bioavailability is what does the difference, bioperine is probably the best for absorption.

Is Bioperine available as a supplement? The curcumin(NSI) I had been taking contained it but I stopped that particular brand as stated earlier in this thread. I am now taking the NOW brand and it contains no Bioperine.
Do you feel Bioperine is a essential for bioavailability?

Cureo, I take 2 in the morning, 1 at lunch, 2 in the evening. There are no additives in the curcumin I take but I am also taking 10 enzyme tabs a day, 3000mg ganoderma lucidum, 4050mg licorice, inosine and the usual vitamin including 2400mg NAC, selenium, glutathione, vit b,c,d etc. I've never noticed anything with the other supplements but I do think the high dose curcumin helps.

Nop, bioperine (pepper extract) as far as I know isn't available as a supplement but increases in most cases absorption, I give to my wife 1gr/day curcumin from Food Science, @Schnittke do you know if this brand has heavy metals according to cunsomerLabs?
On the other hand if you take enzymes etc they all help and probably absorption is better, who knows!

@gibbledygook what medicines you take except the supplements you mention above?

My wife follows BBD, take what Bob Lawrence/BBD suggests plus Lauricidin (monolaurin fatty acid from coconut which eliminates candida and most other lipid coated viruses as EBV, Herpes etc), acidophilus, E-tocotrienol, Acetyl-L-carnitine and 3mg Low Dose Naltrexone.
I am thinking of adding inosine, what do you believe 2gr/day will help her( RRMS one year now with 3-4 mild relapses) and what results have you had with inosine?
Tomorrow she has a blood analysis for uric acid, T3,T4,TSH, liver etc so will see her uric acid levels.

Here is a link to an abstract of a presentation to be made at the AAN conference in April (thanks to Bromley for the heads up). I don't know if I'm violating their embargo by posting a link, but I'll post it and beg for forgiveness if it's wrong.

This is a test tube study involving quercetin. They make some promising findings. The other thing I found interesting was that it was funded by a group I had never heard of called "Jog for the Jake". Attached is a link to them too.

http://www.abstracts2view.com/aan2008ch ... 8L_P07.145

http://www.jogforthejake.com/

I tried taking this turmeric supplement from Oregon's Wild Harvest. I went through two bottles of the stuff and didn't notice much benefit so I went back to whole turmeric. It includes bioperine and you read more about that at http://www.bioperine.com. Since whole turmeric is about 3% curcumin by weight, I calculated that each capsule was roughly the equivalent of 1 TB whole turmeric though I don't take nearly that much. I've thought about adding some finely ground black pepper into the turmeric but I don't know if that would help much.

NHE

Dim, I take 2000mg of inosine a day. I never noticed any increase/decrease in tingling such as I am on these maximised curcuminoids. I also suffered two treatment (long term metronidazole & infrared sauna and then superoxide dismutase) induced relapses on inosine so its preventative powers are limited. My uric acid levels are usually in the middle so maybe I should take more but then I don't want to get gout! This and 3000mg ganoderma lucidum, 4000mg licorice, 5000mg max curcuminoids, 3000mg green tea, 600mg reserveratrol, selenium, 2400mg NAC, glutathione are my specifically MS oriented supplements but I also take vit b,c,d,e, calcium, magnesium, alpha lipoic acid. I'm interested about your coconut and epstein barr comment...I shall investigate further on pubmed.

This isn't cure or medicine mate but at least in laboratory tests it disables some lipid coated viruses, have a look and google it (monolaurin):
http://www.lauricidin.com/micro.asp

Regarding inosine every clinical trial I read shows great promises so I wonder why in your case the results were negative, probably due to other exogenous factors such metronidazole and dismutase?

Do you guys suppose this Bioperine supplement would help with bioavailability if taken with curcumin or would the curcumin need to have the Bioperine integrated within each capsule to be effective?

http://www.amazon.com/Source-Naturals-B ... B000F4WKVI

As far as I know bioperine could be taken along with curcumin with same results (bear in mind the stomach needs some time to digest caps shell) but if you take quercetin or other enzymes they all help if not more at least the same.
Of course an easy way is to open the curcumin caps and mix the powder with bioperine or quercetin.
In clinical trials doctors used injections of curcumin to rats so remains unclear if oral taken curcumin has the same result but as with any other supplement you never know how much it helps, isn't a medicine that acts directly positive or negative.
I use also E-tocotrienol (form of vitamin E) that also inhibits EAE in rats and has 50-60 times better antioxidant properties than E-tocopherol I may be one of the first that uses this against MS though!

Ok, we gott'em.

Kim's taking 4000 a day. I will have to update the listing of regimin soon. I got them at the vitamin shoppe.

Ken