This Is MS Multiple Sclerosis Knowledge & Support Community

Here's a nice drawing of one...

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Went back to creatine supplements in the last couple of weeks. Stopping didn't change the spasms. We think the painful spasms were due to excessive heat in LA, and not the creatine.

Jeff does well on 6g. of powder mixed in his morning juice or coffee. The powder doesn't have a taste. It's helping him get thru the afternoon without a nap, and now that the weather is cooler, his spasms and pain are less.
whew,
AC

Hi Cheerleader et al,

I've recently considered taking creatine....found some articles that i interpret as being good for fighting glutamate issues in the brain....anybody have a take on this?

The protective effects of creatine against glutamate cytotoxicity have been demonstrated in neuronal cells and animal models of neurodegenerative diseases. The mechanisms underlying creatine neuroprotection against glutamate-induced cell death are understood poorly. For the first time, we demonstrate a correlation between the protective effect of creatine and the modulation of Ras-mediated redox-dependent signaling pathways, which involve nuclear factor B (NF-B) and reactive oxygen species (ROS). In primary cerebrocortical cultures of mixed neurons and glia, creatine significantly reduced glutamate-induced cell death. The increase in cell survival was accompanied by increased generation of oxygen radicals and decreased levels of farnesylated Ras and IB, an inhibitor of NF-B. Non-farnesylated Ras and ROS-dependent activation of NF-B have been shown to promote neuronal survival. Our data suggest that creatine may enhance survival signaling via activation of the Ras/NF-B system. Possible mechanisms underlying the protective effect of creatine are discussed, including normalization of cellular GTP levels. © 2004 Wiley-Liss, Inc.
ad that creatine

I wanted to bump this thread in light of the new thread highlighting creatine's therapeutic role in brain injuries. http://www.thisisms.com/ftopict-16301.html

Does anyone have any experience with creatine they'd like to share?

hey everyone! just wondering about creatine supplementation and effects on the liver. It's my understanding extra creatine supplementation over stresses the liver and can lead to liver disease if used improperly. But then again, I'm still learning when it comes to MS.

Wishing everyone well, as always!