Simple strategy: Doxycycline for 2-3 weeks, then "pulsing"
Posted: Sat Nov 21, 2015 8:06 pm
I am new to this forum, but not new to the topic.
I suspected MS early in the 1990s, read everything I could find on MS causation = etiology, had the impression that it might be a severe form of late (tick) neuroborreliosis.
However, I have been "sero-negative" on repeated testing in 1991 and following years (twice negative in CFS), whatever this means. (From what I have read - a lot! - I have no confidence in such tests as a means to "exclude" tick (neuro)borreliosis.)
After a try with expensive i.v. ceftriaxone in 1993 and slow return of some symptoms over the following months I read a suggestion to use oral doxycycline (doxy) after ceftriaxon.
After a short course of ceftriaxone in 1995 I started on doxy in Jan. 1996, 3x 100 mg per day for 17 days.
After a long pause (more than a year...) I had the impression that my "problem was not solved / cured": I started to experiment with pulses - and after quite a while came up with just 2 days per month of high dose doxy: 300-100-100-100-100-100 mg at ca. 8 hour intervals.
With this scheme I have stayed until now, more than 15 years - without problems from my disease or the doxy. (Ca. 100x 100 mg = ca. 10 g per year, at "rediculously" low cost. Compare ca. 4000 GB pounds over the first year of the "Wheldon protocol", according to Sarah Longlands.)
I had quite a lot of small scars, up to 3mm, on MRT, done on own initiative and cost in 1995 (that is after the first i.v. ceftriaxone series; no Gd extravasation), low grade bbb impairment, nystagmus and a number of symptoms compatible with MS, but never got an MS diagnosis. (Late in the 1990s followed several new symptoms, which may be the consequence of vitamin B12 deficiency...)
--------------------------------------------------------
Could it be that 2-3 weeks of doxycycline stop MS (at least for a time, maybe several months, a year)? I think it could.
The most important argument are the findings of Prof. Gabriel Steiner (1883-1965), who had the hypothesis of a chronic CNS infection with spirochetes about a century ago (in analogy to some patients with late neurosyphilis, clinically indistiguishable from MS).
In 1922 he presented evidence that the hypothetical infection most probably was transmitted by ticks. He developed a silver staining technique to make the very slim spirochetes visible in CNS tissue and started presenting results in the late 1920s, followed by a long review in 1931:
http://link.springer.com/book/10.1007%2 ... 62-28529-9
(Scrolling down you can view two pages each with the start of a new chapter...)
http://www.amazon.com/Krankheitserreger ... 3662270501
"Look inside" allows searches in the whole 200 page book.
There are no translations, as far as I know.
In 1962 G.Steiner published a summary of his life-long work on MS etiology:
http://link.springer.com/book/10.1007%2 ... 42-87571-7
If you scroll down to the chapter "Die Spirochaeta myelo..." and click on "Look inside", then go to the second preview page offered (p.37 in the book) you see 4x4 = 16 microphotos of spirochetes in active MS lesions. Later on they are classified as borreliae.
In ?1981 Willy Burgdorfer discovered borreliae in ticks he had collected, soon idetified as the causal agent of "Lyme disease", including late (CNS) neuroborreliosis - which clinically is indistiguishable from MS.
The conclusion is obvious: G.Steiner discovered B.burgdorferi in active MS lesions as early as the 1920s, including the transmission by ticks.
How is (neuro)borreliosis treated? Well, by 2-3 weeks of doxycycline, 200-300 mg per day, according to several guidelines.
It should be mentioned that G.Steiner in his 1962 book already listed more than half a dozen findings by other independent groups supporting his discovery (but he was the only one to show the localisation of the chronic borrelial infection to the active MS lesions), i.e. Newman et al. from Stanford
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13608292/
Since then much more evidence has been published supporting the G.Steiner discoveries, i.e. by the Brorsons and collegues from Norway in 2001
http://www.ncbi.nlm.nih.gov/pubmed/11787831
Dr. Judith Miklossy has repeated the histopathological work of G.Steiner with modern methods (immunofluorescence...) and similar results (personal communication), but unpublished, as far as I know. (Her major work is on spirochetal etiology of Alzheimer's disease, worthy of a Nobel Prize...)
Doxycycline obviously is very effective in MS, even at a low dose of 100 mg per day, see
http://archneur.jamanetwork.com/article ... eid=795219 and
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24250865/
ALL this is completely ignored by mainstream neurology!
Here in Germany a number of definitely diagnosed MS patients have tried doxycycline for 2-3 weeks and report improvements (no relevant side effects), as soon as very few days from the start: This is another proof of the theory of Prof. Gabriel Steiner.
I could go on with further evidence, but I think this suffices to demonstrate that MS is a severe form of late (CNS-)neuroborreliosis and can successfully be treated with a relatively short course of oral doxycycline.
Continuous treatment is unknown in tick borreliosis (unlike the various protocols in case of MS, i.e. in the studies mentioned above, or in others with minocycline).
In order to prevent relapses the pulse scheme developed by me might work, preventing the reconversion or rather multiplication of borreliae reconverted from the cystic forms demonstrated in MS CSF by Brorson et al. 2001 (see link above).
---------------------------------------------------
My final conclusion is that MS is an active chronic CNS infection, which should be treated as such.
Of course there is the possibility that other causes might produce MS (McDonald criteria...): we could deal with that once the fraction of CIS and early active MS patients not reacting to "standard doxycycline treatment" has been determined. I expect this fraction to be small...
I already have mentioned that B.burgdorferi might impair the walls of veins, including (varicose) veins on the legs where most ticks bite (in adults):
http://www.thisisms.com/forum/post237741.html#p237741
-- second last paragraph of my post at the end of that page.
Has anyone seriously considered the possibility that CSSVI might be the result of a chronic infecion of the venous wall, namely by B.burgdorferi? I have stated that possibility several times before in German.
Certainly someone in this forum knows some scientist interested in the cause of varicosis and might ask to investigate in this direction? The main impairment of blood flow in the CNS in MS will be at the level of venules and has to be treated by treating the causal infection, I am convinced.
(Btw: is any antibiotic used in venoplasty? Could this possibly explain some of the improvements seen after the "liberation procedure"?)
Prof. Gabriel Steiner suggested to cure (control?) MS by antimicrobial therapy as early as 1922, as far as I am aware. Doxycycline (obviously the agent of choice) has been available for about half a century by now.
50 years after the death of G.Steiner it is high time to test if his vision is valid.
chenman
I suspected MS early in the 1990s, read everything I could find on MS causation = etiology, had the impression that it might be a severe form of late (tick) neuroborreliosis.
However, I have been "sero-negative" on repeated testing in 1991 and following years (twice negative in CFS), whatever this means. (From what I have read - a lot! - I have no confidence in such tests as a means to "exclude" tick (neuro)borreliosis.)
After a try with expensive i.v. ceftriaxone in 1993 and slow return of some symptoms over the following months I read a suggestion to use oral doxycycline (doxy) after ceftriaxon.
After a short course of ceftriaxone in 1995 I started on doxy in Jan. 1996, 3x 100 mg per day for 17 days.
After a long pause (more than a year...) I had the impression that my "problem was not solved / cured": I started to experiment with pulses - and after quite a while came up with just 2 days per month of high dose doxy: 300-100-100-100-100-100 mg at ca. 8 hour intervals.
With this scheme I have stayed until now, more than 15 years - without problems from my disease or the doxy. (Ca. 100x 100 mg = ca. 10 g per year, at "rediculously" low cost. Compare ca. 4000 GB pounds over the first year of the "Wheldon protocol", according to Sarah Longlands.)
I had quite a lot of small scars, up to 3mm, on MRT, done on own initiative and cost in 1995 (that is after the first i.v. ceftriaxone series; no Gd extravasation), low grade bbb impairment, nystagmus and a number of symptoms compatible with MS, but never got an MS diagnosis. (Late in the 1990s followed several new symptoms, which may be the consequence of vitamin B12 deficiency...)
--------------------------------------------------------
Could it be that 2-3 weeks of doxycycline stop MS (at least for a time, maybe several months, a year)? I think it could.
The most important argument are the findings of Prof. Gabriel Steiner (1883-1965), who had the hypothesis of a chronic CNS infection with spirochetes about a century ago (in analogy to some patients with late neurosyphilis, clinically indistiguishable from MS).
In 1922 he presented evidence that the hypothetical infection most probably was transmitted by ticks. He developed a silver staining technique to make the very slim spirochetes visible in CNS tissue and started presenting results in the late 1920s, followed by a long review in 1931:
http://link.springer.com/book/10.1007%2 ... 62-28529-9
(Scrolling down you can view two pages each with the start of a new chapter...)
http://www.amazon.com/Krankheitserreger ... 3662270501
"Look inside" allows searches in the whole 200 page book.
There are no translations, as far as I know.
In 1962 G.Steiner published a summary of his life-long work on MS etiology:
http://link.springer.com/book/10.1007%2 ... 42-87571-7
If you scroll down to the chapter "Die Spirochaeta myelo..." and click on "Look inside", then go to the second preview page offered (p.37 in the book) you see 4x4 = 16 microphotos of spirochetes in active MS lesions. Later on they are classified as borreliae.
In ?1981 Willy Burgdorfer discovered borreliae in ticks he had collected, soon idetified as the causal agent of "Lyme disease", including late (CNS) neuroborreliosis - which clinically is indistiguishable from MS.
The conclusion is obvious: G.Steiner discovered B.burgdorferi in active MS lesions as early as the 1920s, including the transmission by ticks.
How is (neuro)borreliosis treated? Well, by 2-3 weeks of doxycycline, 200-300 mg per day, according to several guidelines.
It should be mentioned that G.Steiner in his 1962 book already listed more than half a dozen findings by other independent groups supporting his discovery (but he was the only one to show the localisation of the chronic borrelial infection to the active MS lesions), i.e. Newman et al. from Stanford
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13608292/
Since then much more evidence has been published supporting the G.Steiner discoveries, i.e. by the Brorsons and collegues from Norway in 2001
http://www.ncbi.nlm.nih.gov/pubmed/11787831
Dr. Judith Miklossy has repeated the histopathological work of G.Steiner with modern methods (immunofluorescence...) and similar results (personal communication), but unpublished, as far as I know. (Her major work is on spirochetal etiology of Alzheimer's disease, worthy of a Nobel Prize...)
Doxycycline obviously is very effective in MS, even at a low dose of 100 mg per day, see
http://archneur.jamanetwork.com/article ... eid=795219 and
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24250865/
ALL this is completely ignored by mainstream neurology!
Here in Germany a number of definitely diagnosed MS patients have tried doxycycline for 2-3 weeks and report improvements (no relevant side effects), as soon as very few days from the start: This is another proof of the theory of Prof. Gabriel Steiner.
I could go on with further evidence, but I think this suffices to demonstrate that MS is a severe form of late (CNS-)neuroborreliosis and can successfully be treated with a relatively short course of oral doxycycline.
Continuous treatment is unknown in tick borreliosis (unlike the various protocols in case of MS, i.e. in the studies mentioned above, or in others with minocycline).
In order to prevent relapses the pulse scheme developed by me might work, preventing the reconversion or rather multiplication of borreliae reconverted from the cystic forms demonstrated in MS CSF by Brorson et al. 2001 (see link above).
---------------------------------------------------
My final conclusion is that MS is an active chronic CNS infection, which should be treated as such.
Of course there is the possibility that other causes might produce MS (McDonald criteria...): we could deal with that once the fraction of CIS and early active MS patients not reacting to "standard doxycycline treatment" has been determined. I expect this fraction to be small...
I already have mentioned that B.burgdorferi might impair the walls of veins, including (varicose) veins on the legs where most ticks bite (in adults):
http://www.thisisms.com/forum/post237741.html#p237741
-- second last paragraph of my post at the end of that page.
Has anyone seriously considered the possibility that CSSVI might be the result of a chronic infecion of the venous wall, namely by B.burgdorferi? I have stated that possibility several times before in German.
Certainly someone in this forum knows some scientist interested in the cause of varicosis and might ask to investigate in this direction? The main impairment of blood flow in the CNS in MS will be at the level of venules and has to be treated by treating the causal infection, I am convinced.
(Btw: is any antibiotic used in venoplasty? Could this possibly explain some of the improvements seen after the "liberation procedure"?)
Prof. Gabriel Steiner suggested to cure (control?) MS by antimicrobial therapy as early as 1922, as far as I am aware. Doxycycline (obviously the agent of choice) has been available for about half a century by now.
50 years after the death of G.Steiner it is high time to test if his vision is valid.
chenman