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Statins can also be quite hard on the liver but when taking antibiotics isoniazid and rifampicin are the WORST!! They gave me hepatitis. I've always taken drugs like sweets!

When it comes to weighing the potential of liver damage from taking doxycycline, azithromycin (or roxithromycin), and metronidazole (or tinidazole) against any statin, I'd take my chances with the abx every time.

Frank wrote:Statins are in trials for MS they are expected to have an antiinflamatory and maybe neuroprotective mechanism of action.

and some research has found that they have a positive effect on BBB integrity.

The past days I started to feel better again: Headache, jointpain and elevated temperature got much better.

This night I woke up with a really bad pain in my stomach - after some hours I had to vomit which made my stomach much better but raised my temperature again...
I hope the nausea came from the grilled lamb I had at night. And does not indicate that I cant tollerate the ABX.

I'll wait until tonight to take todays ABX - I dont feel specially well at the moment.

--Frank

Frank, if it was the abx you would have experienced it sooner after starting taking them. I would guess it is either the grilled lamb or maybe a winter vomiting virus or something similar. If you really don't feel well tonight and think you may vomit again, leave it until it passes, it won't hurt.

Sarah

My stomach is much better again. I was able to continue my ABX without a break.
Currenty, I dont think I see any sideeffect from the ABX, expect that I feel deadly tired - its 19:00pm here in germany and I can hardly keep my eyes open...

--Frank

My stormach didn't get better since my last post, its not that bad but its a continous twitching and some pressure, especially in the morning.
Maybe I'll have to change something about my probiotics...

Since yesterday I feel my musceles in the leg ache, like after workout, but I did not do anything.

Still I feel very very tired.

What I hadn't mentioned before but is present since I started LDN and got more significant since I take the ABX is, that my urine got darker than usual.

To check the liver and kidney I'll have my first blood screening on friday...

Are all these things(urine, tirednes, muscle ache) quite normal signs for a bacterial die off reaction?

--Frank

You asked:

Are all these things(urine, tiredness, muscle ache) quite normal signs for a bacterial die off reaction?

Yes, they are, some worse in some people than others. I slept most of the time in the first month, others get much worse muscle ache a darker urine, but all par for the course.

Frank wrote:What I hadn't mentioned before but is present since I started LDN and got more significant since I take the ABX is, that my urine got darker than usual.

When i was on abx's. i found that my urine was darker while on flagyl (ie not when I was on just the roxy & doxy). You can even see a photo of the difference over on cpn help CPn Help/4_samples
There was talk on cpn help of how one could leave their urine in the sun, and deduct something (pyphorins or however you spell it) from any colour change.

I got my first blood test results today - everything - especially the liver and kindney - was fine.
Only the value for iron was under the norm (57myg/dl).

And I got one great thing to report:
Since one relapse 1.5 years ago I had a problem when I moved my right foot downwards, the foot automaticly also moved inwards.
Yesterday morning I noticed this symptom had nearly completly gone
away !

My stomach does not hurt anymore - I changed the intake schedule to 100mg Mino in the morning, and 300mg Roxy and 100mg Mino in the evening.
Also I do not feel that terribly tired.

--Frank

I was doing pretty well the past four days, my foot keeps in the very good state I reported in my last post.
My overall state is currently near to where I've been before starting the ABX, so everything is fine with me so far .

I'm going to update every week, as long as there is nothing special to mention.

--Frank

Well, that's good news about your foot, especially since you have found that happening for about year and a half now.

I'm glad also that you have found the best way to take the antibiotics to avoid discomfort. I have always found roxithromycin the easiest thing to take.

Please give your mother my best wishes: I read about her in the LDN forum.

Sarah

It's about 5 weeks that I'm on the protocol and I do feel really well at the moment.
I don't notice any sideeffects from the ABX, anymore.

To balance my too low iron levels I started taking once per day 50mg Fe2+, five days ago.

To see a potential progress I walk the same course every week, since I take the ABX (which can be extended if I feel like).
Two days ago I was on the longest walk since at least three years - 110 minutes aprox 10km.
I did have some motor problems in my walking (especially at the end) but they were centerainly not more severe as I usually experience them after 75 minutes and 7km.

Additionally I think my little numb/tingling feeling in my right foot got a bit better.

I have to take in regard, that my condition always used to change significantly with the weather, which was particularly nice the past week - I feel much bettter when the wheather is sunny.

Anyway, what I'm experiencing at the moment feels really encouraging !

--Frank

Frank, its sunny where you are, you say? It has rained here solidly for about three days and yesterday it was 7° Celsius, gone back to being as cold as what was a very mild winter. I feel better when it is sunny as well, not too hot, but sunny.

I am very envious that you did a 10km walk, though. I couldn't easily do half that, but that is considerably better than when I was at my worst. I hope this continues.

Sarah

Well actually it has been sunny when I was on my long walk. The past two days where full of rain and a temperatures somewhere around 12°...

--Frank