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Dosage?

Posted: Mon Jul 13, 2009 8:15 am
by LR1234
What is the dosage given of the cyclophosphamide?
I found this article online and was wondering if the dosage is similar.

The objective of this case report is to document the possibility that immunoablative doses of cyclophosphamide may provide a long-term remission of multiple sclerosis (MS). We report the case of a 48-year-old woman with definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of cyclophosphamide was accidentally given intravenously in early 1997. For 7 years there have been no signs of disease activity on history, physical examination, or on high-quality magnetic resonance imaging (MRI) with appropriate contrast-enhancement methodology.

Posted: Mon Jul 13, 2009 1:34 pm
by Lyon
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Posted: Mon Jul 13, 2009 1:37 pm
by LR1234
Thanks for the info Lyon

L

Posted: Mon Jul 13, 2009 1:40 pm
by Lyon
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Posted: Mon Jul 13, 2009 1:45 pm
by LR1234
It was an overdose at the time, I suppose because it was unintentional. I think maybe because they felt it worked they are adminstrating it now as a treatment at that dose.

Posted: Mon Jul 13, 2009 2:07 pm
by Lyon
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Posted: Mon Jul 13, 2009 2:37 pm
by LR1234
true, well if it turns how to stop the progression of MS I'm glad it happened! I was also looking for how many trials have been done on revimmune but I couldn't find any apart for the 20 or so patients treated at JH. I am in the UK so have contacted Accentia to see if any trials are being conducted here.

Posted: Mon Jul 13, 2009 2:58 pm
by Lyon
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Posted: Mon Jul 13, 2009 3:40 pm
by chrishasms
That is the lady they thought they had killed and her MS went away and all the docs said, hey we are on to something.

The dose is 50 mg/kg of ideal body weight.

Posted: Mon Jul 13, 2009 4:02 pm
by guitarguy
does anyone know how she is doing today?

Posted: Mon Jul 13, 2009 4:26 pm
by chrishasms
From what I have heard just fine. I asked once and we just mentioned it in passing. She had cancer though so it may have come back who knows.

Posted: Mon Jul 13, 2009 6:08 pm
by Axiom
Lyon wrote:
LR1234 wrote: To make matters even harder to keep track of, Dr Gladstone had been affiliated with JH at one time and then was doing HDC studies with Stonybrook. The JH research we're familiar with and evidently U of Chicago was/is/is going to do HDC research....as Revimmune?? I don't know.

I find it interesting by any name, but I wish I had a better grasp!

Bob

And for yet another wrinkle... Dr. Gladstone is back at JH
I don't know how involved he is with any MS trials though.


Chris,

Any idea why the dosage is calculated using ideal vs actual body weight?


FWIW, I admit I've gone with the ask forgiveness rather than permission paradigm more than once myself. :wink:

Posted: Mon Jul 13, 2009 8:42 pm
by chrishasms
It's ideal body weight not actual body weight. The nurse was shocked because I was the first person who was exactly on the money. It's what you should weigh, not what you do.

Re: Dosage

Posted: Mon Jul 13, 2009 11:33 pm
by NHE
Lyon wrote:I'm not good with math, but looking at the usual mg per kg, 3800 mg doesn't seem to be much of an "overdose"??
3800 mg would be about one day's worth of the Revimmune protocol. For a 150 lb. person they would receive about 3400 mg/day when being treated with Revimmune.

NHE

Posted: Tue Jul 14, 2009 5:57 am
by chrishasms
That is a number actually that sounds really familiar actually NHE. Good call!