Copaxone--Mechanism of Neuroprotection
Posted: Fri Jun 06, 2008 4:46 pm
Hi again
This is old news but I thought I'd post it anyway.
T cell independent mechanism for copolymer-1-induced neuroprotection
Sharon
This is old news but I thought I'd post it anyway.
T cell independent mechanism for copolymer-1-induced neuroprotection
Still doesn't make it any better than placebo, but it looks like whatever it "does" may or may not be dependent on impacting "autoimmune T cells"Despite active investigation of copolymer-1 (Cop-1) for nearly 40 years the mechanisms underlying its neuroprotective properties remain contentious. Nonetheless, current dogma for Cop-1 neuroprotective activities in autoimmune and neurodegenerative diseases include bystander suppression of autoimmune T cells and attenuation of microglial responses. In this report, we demonstrate that Cop-1 interacts directly with primary human neurons and decreases neuronal cell death induced by staurosporine or oxidative stress.
Dendritic cells (DC) uptake Cop-1, deliver it to the injury site, and release it in an active form.
Sharon