I don't think I am going to do copaxone now
Posted: Wed Sep 09, 2009 7:53 am
Hi,
I wrote in another post that my copaxone had arrived and I was planning to take it. I have read a lot of research in diet about proteins leaking into the blood stream which activates the immune system (leaky gut syndrome) I then thought about copaxone. Now the idea of that is to inject proteins directly into the blood stream, now whilst it acts as a decoy for your body to attack whilst you are taking it, if you decide to stop it your immune system is revved up for an attack so will go after the real myelin again maybe at a greater rate....I saw this on another message board:
Once my liver is ok again think I will go back to LDN and stay on the abx
Warning June 11, 2009 (Wikipedia)
"Besides its beneficial effects, Glatiramer acetate also induces immune reactions and an immune memory against myelin, in particular against myelin basic protein (MBP). [6] This has two important implications. Firstly, Copaxone might increase the risk of an individual with CIS by a large factor [7][8] since about 40% of these patients have not yet mounted an immune response to MBP. The study behind the FDA approval of the drug for Copaxone (the PRECISE trial) had the existence of two large (>6mm) active lesions at CIS presentation as enrollment criterion, and there exist no data on patients with less severe presentations of CIS. The high risk patients singled out by PRECISE are more likely to already have mounted an MBP immune response [9]. Approval of the drug for CIS in general is misleading and potentially hazardous. Secondly, if ever discontinued by a patient, the beneficial effects provided by continuous administration of antigenes ceases, and the harmful effects of induced immune reaction against MBP take over. This could negatively affect (i.e. increase the relapse rate and disability progression) of MS patients who interrupt Copaxone for any reason, for example if they decide to switch to a new drug".
Posted on 06/18/09, 03:06 pm
I wrote in another post that my copaxone had arrived and I was planning to take it. I have read a lot of research in diet about proteins leaking into the blood stream which activates the immune system (leaky gut syndrome) I then thought about copaxone. Now the idea of that is to inject proteins directly into the blood stream, now whilst it acts as a decoy for your body to attack whilst you are taking it, if you decide to stop it your immune system is revved up for an attack so will go after the real myelin again maybe at a greater rate....I saw this on another message board:
Once my liver is ok again think I will go back to LDN and stay on the abx
Warning June 11, 2009 (Wikipedia)
"Besides its beneficial effects, Glatiramer acetate also induces immune reactions and an immune memory against myelin, in particular against myelin basic protein (MBP). [6] This has two important implications. Firstly, Copaxone might increase the risk of an individual with CIS by a large factor [7][8] since about 40% of these patients have not yet mounted an immune response to MBP. The study behind the FDA approval of the drug for Copaxone (the PRECISE trial) had the existence of two large (>6mm) active lesions at CIS presentation as enrollment criterion, and there exist no data on patients with less severe presentations of CIS. The high risk patients singled out by PRECISE are more likely to already have mounted an MBP immune response [9]. Approval of the drug for CIS in general is misleading and potentially hazardous. Secondly, if ever discontinued by a patient, the beneficial effects provided by continuous administration of antigenes ceases, and the harmful effects of induced immune reaction against MBP take over. This could negatively affect (i.e. increase the relapse rate and disability progression) of MS patients who interrupt Copaxone for any reason, for example if they decide to switch to a new drug".
Posted on 06/18/09, 03:06 pm