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HIV, HHV,... stenosis ?
Posted: Wed Mar 03, 2010 5:15 am
by ttt1
some high load viruses can cause stenosis
"The CT angiography revealed coronary atherosclerosis in 59 percent of the HIV-infected patients, compared with only 34 percent of controls."
http://www.harvardscience.harvard.edu/m ... tudy-finds
Herpes virus implicated in clogging of arteries, November 1986
http://www.nytimes.com/1986/11/18/scien ... eries.html
Posted: Wed Mar 03, 2010 5:31 am
by Algis
Those are arteries. Does it apply to veins?
Posted: Wed Mar 03, 2010 8:05 am
by cheerleader
Dr. Zamboni's team is studying how viruses such as EBV can contribute to severity of stenosis as endothelial disrupters. Viruses could potentially create worse reflux and occlusion in certain MS patients...more studies ahead.
cheer
Posted: Wed Mar 03, 2010 10:14 am
by Cece
Just googling endothelial disruption turns up some interesting articles.
"Blood-brain barrier disruption in multiple sclerosis"
http://msj.sagepub.com/cgi/content/shor ... source=mfc
"Exposure of endothelium to proinflammatory cytokines (IFN-g, TNF-a and IL-1b) interrupts the BBB by disorganizing cell-cell junctions, decreases the brain solute barrier, enhances leukocyte endothelial adhesion and migration as well as increases expression of class II MHC and promotes shedding of endothelial ‘microparticles’ (EMP). In this review we examine interactions between cytokines/chemokines, activated leukocytes, adhesion molecules and activated C EC in the pathogenesis of BBB failure in MS."
This is from 2003, without the CCSVI paradigm but looking at the vascular side of m.s. Again those adhesion molecules are mentioned. I am assuming proinflammatory cytokines would be what the body makes in response to viruses in general.