Posted: Tue May 25, 2010 2:01 pm
wow Cece...thanks!.. great research and it makes sense.. at my age my internal thermometer has lost it's mind and my research on that topic turned up similar...
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For us hot-heads, that is a question to which we already know the answer!Cece wrote:So the concise question is: what effect does the slowed perfusion in MS have on the temperature of that blood and, if there is an effect, how does it affect the central thermoregulatory function in the hypothalamus?
Thankl-you Eric593. I am very interested in how one can ethically do "sham" surgery. Whether informed consent is sufficient for the risks of the incision and insertion of the catheter is interesting to me. In angioplasty, though, the level of sedation is very low, and although not painful, I think you can feel the catheter moving in the body, so merely numbing the insertion site and sheilding the patient's eyes would not be sufficient. Plus the follow-up requires a warfarin regime, and a patient would know ilf they were receiving a placebo and not the anti-clotting drug. The anti-clotting drug is a risky thing. Those following the CCSVI history know that the one death that happened was due to the anti-clotting drugs that were part of the post-stenting procedure.eric593 wrote:This is the closest I've come to finding a similar sham surgery:Zeureka wrote: Dr Sclafani, I am wondering how such studies could be/will be or have already been started to be performed? Catheter vengography applied to all and for the placebo-group then just not apply the dilatation/ballooning? Without them knowing that it has been done or not? For how long would the improvements be compared in such a study (and by which criteria), and for how long would the placebo group not know it was placebo? Is this a realistic and necessary direction the neurologists are pushing us to go for? Placebo treatments without applying venoplasty?N Engl J Med. 2002 Jul 11;347(2):81-8.
A controlled trial of arthroscopic surgery for osteoarthritis of the knee.
Moseley JB, O'Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP.
Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA.
Comment in:
N Engl J Med. 2002 Jul 11;347(2):137-9.
N Engl J Med. 2002 Jul 11;347(2):132-3.
N Engl J Med. 2002 Nov 21;347(21):1717-9; author reply 1717-9.
N Engl J Med. 2002 Nov 21;347(21):1717-9; author reply 1717-9.
N Engl J Med. 2002 Nov 21;347(21):1717-9; author reply 1717-9.
N Engl J Med. 2002 Nov 21;347(21):1717-9; author reply 1717-9.
N Engl J Med. 2002 Nov 21;347(21):1717-9; author reply 1717-9.
J Bone Joint Surg Am. 2003 Feb;85-A(2):387.
ACP J Club. 2003 Mar-Apr;138(2):49.
Curr Womens Health Rep. 2003 Feb;3(1):63-4.
Summary for patients in:
J Fam Pract. 2002 Oct;51(10):813.
BACKGROUND: Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. We conducted a randomized, placebo-controlled trial to evaluate the efficacy of arthroscopy for osteoarthritis of the knee.
METHODS: A total of 180 patients with osteoarthritis of the knee were randomly assigned to receive arthroscopic débridement, arthroscopic lavage, or placebo surgery. Patients in the placebo group received skin incisions and underwent a simulated débridement without insertion of the arthroscope. Patients and assessors of outcome were blinded to the treatment-group assignment. Outcomes were assessed at multiple points over a 24-month period with the use of five self-reported scores--three on scales for pain and two on scales for function--and one objective test of walking and stair climbing. A total of 165 patients completed the trial.
RESULTS: At no point did either of the intervention groups report less pain or better function than the placebo group. For example, mean (+/-SD) scores on the Knee-Specific Pain Scale (range, 0 to 100, with higher scores indicating more severe pain) were similar in the placebo, lavage, and débridement groups: 48.9+/-21.9, 54.8+/-19.8, and 51.7+/-22.4, respectively, at one year (P=0.14 for the comparison between placebo and lavage; P=0.51 for the comparison between placebo and débridement) and 51.6+/-23.7, 53.7+/-23.7, and 51.4+/-23.2, respectively, at two years (P=0.64 and P=0.96, respectively). Furthermore, the 95 percent confidence intervals for the differences between the placebo group and the intervention groups exclude any clinically meaningful difference.
CONCLUSIONS: In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.
PMID: 12110735 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/12110735
Unfortunately gold is an excellent conductor, gold/platinum alloy is efficient too. So this could potentially rule MR out. Try Johns Hopkins though since the size and shape of an implant is important in deciding whether or not MR can take place.. But as Dr Sclafani said in response to my question, the MRV can be skipped and you can go straight to a venogram.Niceflow wrote:Thanks L. for your explanation regarding metal implants & MRI. I did ask my dentist about the material used and here is his answer:
"The bridge is made of a gold and platinum alloy for teeth numbers 13 - 23. It is not an actual implant. This bridge has been glued onto natural teeth and is visible from the outside. It has no intra-osteo metallic components."
Any more comments would be appreciated.
I realize that this could be a completely different situation and combination of metals, but I have a gold crown on a tooth, and have had many MRIs with no problem. Hope that helps-L wrote:Unfortunately gold is an excellent conductor, gold/platinum alloy is efficient too. So this could potentially rule MR out. Try Johns Hopkins though since the size and shape of an implant is important in deciding whether or not MR can take place.. But as Dr Sclafani said in response to my question, the MRV can be skipped and you can go straight to a venogram.Niceflow wrote:Thanks L. for your explanation regarding metal implants & MRI. I did ask my dentist about the material used and here is his answer:
"The bridge is made of a gold and platinum alloy for teeth numbers 13 - 23. It is not an actual implant. This bridge has been glued onto natural teeth and is visible from the outside. It has no intra-osteo metallic components."
Any more comments would be appreciated.
i am not aware of any proven association between ccsvsi and other venous valve problems.PCakes wrote:Is it safe to say that if you have a jugular vein valve issue ..good chance you'll find the same in other areas.. ? Many of the symptoms listed below are also known as MS symptoms?drsclafani wrote: The circulation in the hands and feet is affected by the autonomic nervous system in ms. this leads to purple feet and hands.
somehow, relieving the venous outflow improved autonomic nerve function
Symptoms of Venous Insufficiency..signs and symptoms mentioned in various sources for Venous Insufficiency includes the 12 symptoms listed below:
Throbbing leg
Cramping
Burning sensation in leg
Leg fatigue
Nonhealing ulcers in foot
Swollen limb
Thickened skin on affected limb
Shiny skin on affected limb
Discolored skin on affected limb
Leg heaviness
Leg redness
Varicose veins
Thank you again..
Although gold is an excellent conductor of electricity (arguably the best conductor metal), it is non-ferrous (non-magnetic), and would not be subject to the heating that ferrous metals would be. I have a very large gold crown, and have had many MRIs with it in my mouth. The only real problem is that it tends to cause a "black hole" on the images.L wrote:Unfortunately gold is an excellent conductor, gold/platinum alloy is efficient too. So this could potentially rule MR out. Try Johns Hopkins though since the size and shape of an implant is important in deciding whether or not MR can take place.. But as Dr Sclafani said in response to my question, the MRV can be skipped and you can go straight to a venogram.Niceflow wrote:Thanks L. for your explanation regarding metal implants & MRI. I did ask my dentist about the material used and here is his answer:
"The bridge is made of a gold and platinum alloy for teeth numbers 13 - 23. It is not an actual implant. This bridge has been glued onto natural teeth and is visible from the outside. It has no intra-osteo metallic components."
Any more comments would be appreciated.
But I did not see any indication that the patients KNEW they were on the placebo. If they did it wouldn't be a blinded trial.eric593 wrote:
There doesn't seem to be any issue with a patient figuring out if they're on the active or placebo drug as the placebo group had a very high % of the same side effects as the active drug group.
While I cannot speak about others, my IR prescribed 75mg Plavik for 30 days starting on the day of the balloon procedure.MS_mama wrote:Dr. Sclafani, I was wondering how high you think the risk of thrombosis is post-angioplasty, considering that other doctors are not prescribing anticoagulants after the procedure unless stents are involved. I am considering if the risk is high enough if I should request it anyway, even though its not part of their protocol. What are your thoughts and what regimen do you prescribe after the angioplasty?