This Is MS Multiple Sclerosis Knowledge & Support Community

Ruthless67 wrote:

In Kuwait the MS patient is increasing and it is estimated about 3000 – 6000 patients.

In conclusion, the incidence and prevalence of MS in Kuwait has increased between the early and late 1990s with no signs of leveling off.

So my question is why the increase? And it’s not just Kuwait seeing this increase.

Our results so far shows strong link between CCSVI and M.S.

It has also been established that CCSVI is a congenital disorder and precedes the development of MS.

OK, so what starts all this congenital disorder? How do we get to the bottom of that? What is X if: X = congenital disorder = MS

I can’t believe it’s just genetic and passed by our genes. That wouldn’t explain it’s rapid increase.

I’m thinking it’s organic in origin. Because MS has been with us for quite a while.

More like a lack of something in parents diet like Vitamin D or because, starting with our parents generation, we don’t cook with bones anymore, so we get much less collagen in our diets.

Or maybe it’s the pesticides used in farming since the 40’s that we’ve all been ingesting like PCB, DDT etc; or the fertilizers, or pollution in general. But wait, MS has been around much longer than these things, so again,

I’m thinking it’s organic in origin. But again, something that’s been present all along, just getting stronger in nature over the last few years.

I think maybe it’s something naturally occurring but in an overgrowth state such as Candida albicans where the mother has this condition and in the womb the fetus then has the same condition and it effects the vascular system during it’s developmental stage.

The truncular venous malformation (VM) represents an embryologically defective vein where developmental arrest has occurred during the vascular trunk formation period in the 'later stage' of the embryonic development.

I can’t find it, but I’m pretty sure Dr. Zamboni eluded to something along these lines in his research. I believe I read it paraphrased on another thread.

Or it could be fungal, even parasitic in nature that follows the same scenario as above. Kind of like what they learned about the origin of ulcers.

But if it is organic in origin, why the increase now? What has changed?

The increasing cases of MS have been steady, but these documented stats regarding this 7 year period, 1993 - 2000, in Kuwait is very powerful.

As we get closer to answers, there are so many questions…………I believe it is a puzzle!

The increasing cases of MS have been steady, but these documented stats regarding this 7 year period, 1993 - 2000, in Kuwait is very powerful.

Background and Purpose— Increased mortality after stroke is associated with brain edema formation and high plasma levels of the acute phase reactant C-reactive protein (CRP). The aim of this study was to examine whether CRP directly affects blood–brain barrier stability and to analyze the underlying signaling pathways.

Methods— We used a cell coculture model of the blood–brain barrier and the guinea pig isolated whole brain preparation.

Results— We could show that CRP at clinically relevant concentrations (10 to 20 µg/mL) causes a disruption of the blood–brain barrier in both approaches. The results of our study further demonstrate CRP-induced activation of surface Fc receptors CD16/32 followed by p38-mitogen-activated protein kinase-dependent reactive oxygen species formation by the NAD(P)H-oxidase. The resulting oxidative stress increased myosin light chain kinase activity leading to an activation of the contractile machinery. Blocking myosin light chain phosphorylation prevented the CRP-induced blood–brain barrier breakdown and the disruption of tight junctions.

Conclusions— Our data identify a previously unrecognized mechanism linking CRP and brain edema formation and present a signaling pathway that offers new sites of therapeutic intervention.

sbr487 wrote:Cheer, are you a teacher by any chance? because, every time we digress, you beat us back onto track.

BTW, just wanted to know if you are accepting any donations for CCSVI Alliance?

the list of nitric oxide disrupters is a veritable laundry list of modern, industrialized living.

In Kuwait, at family gatherings and social events, food is always at the top of the menu.
Friends meet at restaurants two or three times a week and if you don't want to go out, Western fast food chains like Burger King will deliver tasty, high-fat meals to your front door.
At family occasions, the more opulent the spread the greater the social status conferred. Tables groan under the weight of multi-course banquets laid on by competitive hostesses, often aided by maids.
But, in the oil-rich Gulf state where scorching summers keep people indoors, this appetite for excess is taking its toll. Kuwait is one of the fattest nations on earth -- and it is affecting people's health.
Just over 74 percent of the population is overweight, according to the World Health Organization (WHO) and this "obesity epidemic" is contributing to a rise in heart disease and diabetes.

WHO says around 14 percent of Kuwaitis currently suffer from diabetes and it is on the rise.
"[Being] overweight and obesity have been gradually increasing for the past 15 years," Nawal Al Hamad, Head of Nutrition at Kuwait's Ministry of Health, told CNN.
The underlying causes are complex, but an abundance of food and sedentary lifestyles are major factors, according to Hamad.

frodo wrote:What is there is simply no increase in real incidence but in reported incidence? Some years ago there was no possible diagnosis before death, and at that time it really didn't matter. What if we are only seeing an advance in diagnosis?

cheerleader wrote:Cah-
Thanks for the CVI/obesity links...
I believe you can have a congenital venous malformation, and environmental/lifestyle factors will make stenosis and reflux even worse....just as you can have a genetic predisposition to high cholesterol or stroke. These malformations may start out "baby sized" and grow, due to vasoconstriction and endothelial disruption. This may be why we are seeing higher rates of, not only MS, but all autoimmune diseases.
cheer