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The problem with the EAE model, Bill, is that in order to create it, you need to inject a foreign antigen into the body...so the assumption is that some foreign matter enters the CNS and creates this reaction.
In encephalomyelitis (a differential for MS)- the reaction of inflammation and demyelination is created by a virus or vaccine.
Putnams' dogs developed an encephalitic reaction (inflammatory/demyelination) that looked just like MS WITHOUT introducing any foreign matter....simply by blocking the cerebral veins. Ockham's Razor.
Why do we continue to use a model which needs that extra step of foreign matter injection into the CNS of animals? I think it's because immunologists can "cure" EAE....but it takes a VASCULAR doctor to stop venous reflux and congestion. Venous doctors have never studied MS...until now.
cheer
Ockham and Zamboni are the originalssmokey wrote:Awwww, thought I might have been original.....never mind. Still a damn fine principle.
This is especially true in case of MS since routine method of explaining MS has failed for such a long time. As they say, when everything fails, start all over again. Thats the damn thing the neuros are not capable of. They dont want to climb down from the castles they have build in air all over the years ...smokey wrote:Occam's razor (or Ockham's razor[1]) is the principle that "entities must not be multiplied beyond necessity" (entia non sunt multiplicanda praeter necessitatem). The popular interpretation of this principle is that the simplest explanation is usually the correct one...........
except the US and Canada....LR1234 wrote:I reckon by this time next year CCSVI will be recognised as a treatable condition in every country.
- Slovakia - so far 8 procedures, they use stents, doctors are not sure yet but so far they "only" had to have permission from the hospital1eye wrote:I have at times tried to make a list of countries where Liberation is allowed:
Bulgaria
Italy
Germany
France
UK
US (if not in a trial. otherwise IRB footdrag)
Poland
Mexico
NOT CANADA
Kuwait
Jordan
any other? I can't remember them all.
Occam's -- A great shave, every time...