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with many thanks and I do hope that it is okay to drag and share this over here..



Also, I have a question.. (sorry I am not fluent in medical terminology)..
If your veins are insufficient, causing disturbed blood flow, and there are issues with circulation back to the heart would this not also cause disturbed blood flow problems in your arteries? The blood flow in would be disturbed by the blood flow out? Resulting in inflammation of the arterial walls as well as the venous walls?

Dr. Sclafani has said that outflow determines inflow, so having slow outflow by ccsvi makes for slow inflow. I don't think the turbulence stretches back too far...remember arteries go into smaller and smaller vessels until it is capillary-sized and then into venules and bigger and bigger venous vessels again. The turbulence is probably limited to relatively near the blockage and corollaries?

(Just read the article, great find, and it makes me think I was wrong yesterday with what I said about not being sure if CCSVI caused inflammation within the veins!!)

thanks Cece!!.. the root of my wonder is that.. cario vascular/ heart disease is prevalent in my family. Is it all tied together..? dunno..but i do know that Joan's recipe for healthy living is a good one..for us and all.
Have a great day!

I have a history of cardiovascular issues with my dad as well. It made me wonder if CCSVI is tied to some genetic marker for predisposition to vascular conditions/disorders, and perhaps manifests itself differently in some people vs. others.

My dad has had two strokes and many blood clots, by the way.

..my dad had his first heart attack mid thirties.. followed by 5 more. We lost him in his early fourties.. doctors never did source the cause. He was a healthy and active man.
Yes, I wonder too...

PFO is also on my list for my next check-up. About 25pc of MSer's
have this condition. It is thought to be one of the main risk factors for idiopathic stroke. Neurologists often ask Cardiologists here to check for
the defect - no problem. Migraine sufferers can also have an ultrasound
looking for any level of defect in the valve.

Hi Mangio,

What is PFO?

Patent Foramen Ovale, heart defect. If I am understanding this
correctly a valve between the left and right chamber of the heart can have different types of defects and if not fully sealed will permit
unfiltered blood - potentially with clots - to travel to the brain.
I was amazed to find so many sites with great information
on this topic and some trial info as well.

Apparently a Barrie heart surgeon wrote a column for MacLeans
in June about the issue. I'm going to try to get a back copy.

This will be just of the areas the scientists of the Pan-Vascular
group are working on. Microembolism is another that is common
in neurodegeneration diseases.

It was quite shocking for me to hear how ho-hum most of this
is in scientific circles - especially alzheimers investigators -
and why this should be so earth shattering to ms specialists.
Um..

Thank you Mangio.. yes, the indifference is as puzzling as the opposition?

This study is on mouse arteries not veins, which are physically and physiologically completely different. Please be careful before you apply these results to CCSVI.
Kind regards,
MarkW

MarkW wrote:This study is on mouse arteries not veins, which are physically and physiologically completely different. Please be careful before you apply these results to CCSVI.
Kind regards,
MarkW

Hi Mark--
I actually spoke with a couple of vascular doctors before publishing that note. The endothelial lining of blood vessels is the same in arteries and veins, and disturbed blood flow does indeed create changes to the lining of the vessel and increase localized inflammation.

The affect in arteries is different (in relation to plasmic deposition of fats/clots) but disturbed blood flow will change a venous wall as well, and increase a stenotic environment, even creating thrombi. The docs believe this is why CCSVI progresses over the years. The vascular malformations grow as the body grows, and the disturbed blood flow creates a cycle of inflammation and endothelial disfunction. I'm very careful to check my writing out with the doctors before putting on the Facebook page.
thanks,
cheer