Posted: Mon Aug 23, 2010 4:33 am
hi i looked at what other kinds of deficiencies you see in may thurner, and noticed protein C. i also saw mention of elevated homocysteine.
i looked for homocysteine and protein C together and found this:
Homocysteine and Hemostasis: Pathogenetic Mechanisms Predisposing to Thrombosis
Peter C. Harpel, Xiaoxia Zhang and Wolfgang Borth
http://jn.nutrition.org/cgi/content/abs ... uppl/1285S
Growing evidence suggests that moderately elevated levels of homocyteine are associated not only with arterial thrombosis and atherosclerosis but also with venous thrombosis as well. We have reviewed recent studies that indicate that homocysteine inhibits several different anticoagulant mechanisms that are mediated by the vascular endothelium. The protein C enzyme system appears to be one of the most important anticoagulant pathways in the blood. Homocysteine inhibits the expression and activity of endothelial cell surface thrombomodulin, the thrombin cofactor responsible for protein C activation.
one more on homocysteine and the vascular system:
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507396/
then i searched for homocysteine and zinc, and then i searched on homocysteine and copper. zinc appears to lower homocysteine. there's definitely a connection between homocysteine and copper but i'm not sure i understand it yet so for now just one sample abstract on Hcy and Zn:
Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712914/
check this out too:
Copper toxicity, oxidative stress, and antioxidant nutrients
http://www.ncbi.nlm.nih.gov/pubmed/12821289
i looked for homocysteine and protein C together and found this:
Homocysteine and Hemostasis: Pathogenetic Mechanisms Predisposing to Thrombosis
Peter C. Harpel, Xiaoxia Zhang and Wolfgang Borth
http://jn.nutrition.org/cgi/content/abs ... uppl/1285S
Growing evidence suggests that moderately elevated levels of homocyteine are associated not only with arterial thrombosis and atherosclerosis but also with venous thrombosis as well. We have reviewed recent studies that indicate that homocysteine inhibits several different anticoagulant mechanisms that are mediated by the vascular endothelium. The protein C enzyme system appears to be one of the most important anticoagulant pathways in the blood. Homocysteine inhibits the expression and activity of endothelial cell surface thrombomodulin, the thrombin cofactor responsible for protein C activation.
one more on homocysteine and the vascular system:
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507396/
then i searched for homocysteine and zinc, and then i searched on homocysteine and copper. zinc appears to lower homocysteine. there's definitely a connection between homocysteine and copper but i'm not sure i understand it yet so for now just one sample abstract on Hcy and Zn:
Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712914/
check this out too:
Copper toxicity, oxidative stress, and antioxidant nutrients
http://www.ncbi.nlm.nih.gov/pubmed/12821289