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Too much iron, more severe disease
New Ferrara - September 24, 2010 page 19 Section: Commentary
"It 's another piece of the puzzle that is made," says the researcher Paolo Zamboni.To place a new tile on the mosaic of research on multiple sclerosis was yesterday Professor Rohit Bakshi, Harvard University, came to Ferrara to explain the outcome of a decade of study during which he analyzed the role of iron as a contributory cause of the disease. His line of research was independent from that beaten by Ferrara Zamboni, but its conclusions have been come to intertwine with the results of tests carried out by the researcher and neurologist Bologna Ferrara Fabrizio Salvi on Ccsvi, which have established a hypothetical link between stenosis of the venous vessels in the brain iron accumulation and the onset of multiple sclerosis.

"The current therapies - said the scientist in the main hall of the university - are not effective in stopping the neurodegeneration. Bakshi was able, with a common magnetic resonance imaging to measure the actual concentration of iron in the brain, an operation in the past only run during the autopsy. Plaques and iron stores were associated, but especially "the greater the presence of iron - Bakshi said - the more you exacerbate the effects of the disease." Studies have revealed that the abnormal presence of iron affects the white matter and gray and tends to cause atrophy of certain areas of the brain.

cah wrote:intertwine. Wonderful word! Didn't know it until now.

verflechten is close enough to verklempt for me Smile
Johnson, if anyone can re-grow gray matter, my money is on you.

...However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood.

From the Italian press---Professor Rohit Bakshi of Harvard University came to Ferrara University to discuss how his decade long study of iron deposition in MS brains has now intertwined with Dr. Zamboni's research:
...
its conclusions have been come to intertwine with the results of tests carried out by the researcher and neurologist Bologna Ferrara Fabrizio Salvi on Ccsvi, which have established a hypothetical link between stenosis of the venous vessels in the brain iron accumulation and the onset of multiple sclerosis.
...

This time, it is Professor Rohit Bakshi of Harvard who, after ten years of research, confirms the importance for the scientific hypothesis of a venous origin of multiple sclerosis (deficiency cerebrospinal venous chronic or IVCC CCIVS).

On September 23, 2010, he met Dr. Zamboni at the University of Ferrara (Italy) and detailed the role of iron in multiple sclerosis. However, the two researchers have explored the subject in a completely independent vis-à-vis the other. But their findings lead to the same conclusion: there is more iron in the brain, the more there is an exacerbation of the disease. And the incorrect presence tends to cause atrophy of certain brain regions.

This reinforcement allows medical Paolo Zamboni to declare that a new piece of the puzzle has finally been released. It also fits perfectly with the results of tests performed by Fabrizio Salvi, neurologist and researcher, on a hypothetical link between vein stenosis and the appearance of multiple sclerosis because of the accumulation of iron produced in the brain.

Prof. Bakshi was able to measure the actual concentration of iron in the brain by MRI, which was done before that in autopsies.

These developments argue for an intensification of research (still stalled in France) as demanded by thousands of people affected by this tragic disease. They are also more likely to spin overseas to benefit from angioplasty they are denied at home. It is through this simple process involving the rupture of the blood-brain barrier by eliminating venous stenosis.