i was two years into high dosing d3 at 4000 IU per day, before the real life-threatening trouble started with my magnesium status. i know of no studies that match that dose over that time frame.
i was just coming out of a related chest xray and randomly dropped in to the pharmacy counter to ask some other question. that man saved my life by telling me i needed magnesium. i told him i took it daily. he said, take it more, and make sure you take some away from the vitamin d3. thus began my fun adventures with mag oxide etc.
carolyn dean makes a good point here
http://www.huffingtonpost.com/carolyn-d ... 40931.html
"Personally, I think we should consider that part of the vitamin D deficiency epidemic is an underlying magnesium deficiency. That could mean that we don't really need extraordinarily high doses of vitamin D, but a combination of vitamin D along with magnesium to make the vitamin D work. I often recommend 1,000-2,000iu along with 600 mg of elemental magnesium."
sounds perfect to me (getting as much mag as possible from diet of course). and on that note:
http://whqlibdoc.who.int/publications/2 ... 50_eng.pdf
"the available data suggest that the total magnesium intake must be at least 450–500 mg/day, and drinking-water should contain a minimum of 25–50 mg/l (at present, in the United States, many of our potable water sources contain <10 mg/l). At the turn of the past century, we were ingesting, in the United States, about 450–500 mg of magnesium per day; at present, we are ingesting about 175–248 mg/day" ... "in order to prevent or ameliorate vascular- and cardiac-related disorders, our diets and/or drinking-water (and beverages) should be supplemented with magnesium"
reported daily mag intakes:
Canada..........209–279 mg
France...........284–377 mg
Guam.............270±131 mg
Israel.............228–270 mg
South Africa....228–285 mg
Spain...................366 mg
i like carolyn's other point as well: "In 2011, a British Medical Journal meta-analysis sounded the alarm that "Risks outweigh benefits for calcium supplements."[5] The study indicates that calcium supplements do more harm than good. They cause more cardiovascular events (such as heart attacks and stroke) than the number of fractures they prevent." ie when you load the system with supplements that mess with magnesium, people die.
i've definitely helped people with low response to d3 supplementation improve by adding minerals. waaaay back when i was the one going on about high dose d3, i remember NHE getting his d3 levels sorted with a pretty low dose
and a multimineral. for myself, i definitely noticed a dramatic change in d3 dose response after correcting zinc deficiency (which would have had an effect on mag status too) ooohh so interconnected :S !!
it's clear that the body requires magnesium to handle vit d3. i don't think it's at all wise to only bother with magnesium levels, in the event that vit d3 levels don't respond appropriately to supplementation. it needs to happen right up front, so that people don't make a widespread magnesium problem even worse by making vit d3 the new calcium.
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