hypoplasia of the IJV
Posted: Wed Dec 08, 2010 8:38 am
http://content.onlinejacc.org/cgi/conte ... 5.09.058v1
So to me the point of interest in this abstract is the one case of hypoplasia of the IJV. THAT could be CCSVI. Here in 20 individuals a single case of one-sided hypoplasia was found. If the sample of people was randomly chosen and they were all healthy, finding even one hypoplastic IJV is higher than would be expected?
The presence of one hypoplastic IJV wouldn't guarantee CCSVI, it would depend on the results of a transcranial doppler and how the rest of the blood flow has been diverted.
However even in a healthy population, perhaps that individual would be experiencing a scientifically measureable difference in fatigue, weakness, etc?
This was posted in CCSVI Locator but again it is talking about the other form of valve insufficiency, where blood can flow through the valve but will flow back again under valsalva. (In CCSVI the blood does not flow through in the first place; it is the valve itself as an outflow obstruction that causes the reflux.)Volume 33, Issue 6, Pages 857-862 (June 2007)
Analysis of Internal Jugular Vein Insufficiency—A Comparison of Two Ultrasound Methods
Max Nedelmann, Daniel Teschner, Marianne Dieterich
Received 13 July 2006; received in revised form 23 November 2006; accepted 14 February 2007. published online 24 April 2007.
Abstract
Jugular venous valve insufficiency is a contributing factor to different pathologic conditions. For assessment of insufficiency, two ultrasound techniques have been developed, that are based on very different methodology (direct Doppler assessment versus air contrast ultrasound venography [ACUV]). This study was conducted to compare these two methods to improve comparability of existing studies and diagnostic accuracy in future studies. The function of 40 valves was determined in 20 individuals during a Valsalva maneuver. For direct Doppler assessment, valvular competence was assessed on basis of Doppler recordings, following recently established criteria. Valvular insufficiency in ACUV was diagnosed when reflux of an air-based echo contrast agent through the valve could be detected. With both methods, evaluation of 39 valves was accomplished (one exclusion due to hypoplasia of the corresponding vein). Both methods showed very high agreement in detection rates. All 18 valves being classified as insufficient by Doppler criteria were also insufficient in ACUV. Of 21 valves classified as competent (Doppler), one valve was rated as insufficient in ACUV due to discrete reflux of microbubbles. However, ACUV was inaccurate in evaluation of the left internal jugular vein after injection of the contrast agent into the right cubital vein. High detection rates could only be achieved when this was taken into account. This study shows that detection rates of internal jugular valve insufficiency are very similar with both methods. However, this high agreement required modification of the established protocol of ACUV.
So to me the point of interest in this abstract is the one case of hypoplasia of the IJV. THAT could be CCSVI. Here in 20 individuals a single case of one-sided hypoplasia was found. If the sample of people was randomly chosen and they were all healthy, finding even one hypoplastic IJV is higher than would be expected?
The presence of one hypoplastic IJV wouldn't guarantee CCSVI, it would depend on the results of a transcranial doppler and how the rest of the blood flow has been diverted.
However even in a healthy population, perhaps that individual would be experiencing a scientifically measureable difference in fatigue, weakness, etc?