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When i was diagnosed with MS 8 years ago i was given IV steroids for 3days, i have SPMS with just the one relapse at the beginning that lead to diagnosis,

but after the first IV steroids i would go to my GP once a year stating my legs were worse and he would give me Methylprednisolone, 500mg once a day for 5 days.

To be fair to him i would also exaggerate that i had a relapse as when taking the Methylprednisolone my mobility would improve 95%, but each following year the mobility improvement would be less and less (due to the neurological damage from MS), although still a great improvement,
- as an 18 year old i wanted improved mobility even at a cost.

well i done this yearly steroid 5day dose for 5 years, then i started LDN so stopped the steroids,

I was wondering why i dramatically improved so much on Methylprednisolone ?
is it related to my CCSVI? - IJVs 50% blocked amnd Azygos 90% blocked

However i have recently learnt i have mild hypothyroidism and possible adrenal fatigue - but the adrenal symptoms seemed to have been mostly resolved by the LDN,

I read some people with adrenal fatigue take steroids to treat so was wondering could this be the reason i improved so drastically on high dose short course steroids?
-- i once done a longer course of steroids about 3 weeks i think, starting high dose then slowly tapering down - the great mobility improvements would vanish after i tapered down from the higher doses, so the smaller doses didnt improve my mobility,

also when i woiuld finish the 5 day short course of 500mg daily steroids the improvements would vanish within a day

does anyone else see big improvements when taking steroids in high doses for their ms?

sorry for the long thread and any opinions are appreciated
Adam

Like you, I had dramatic improvement in my mobility on my first course with methylpredinose When the effects of that wore off after a few weeks, I had solumedrol intravenously followed by predizone orally. Little improvement then or with the next round several months later.

That was about 20 years ago and I haven't used it since then. I had serious side effects from both prednizone and solumedrol. I have not taken any medications since.

I think the theory is that predinizone is an anti-inflammatory. I don't know if there's any connection with CCSVI.

Blaze wrote: I think the theory is that predinizone is an anti-inflammatory. I don't know if there's any connection with CCSVI.

Wow. I just wrote "methylprednisolone blood flow" in google and I got this:

Effect of Methylprednisolone on Regional Blood Flow and Recovery of Somatosensory Evoked Potentials

http://www.ejbjs.org/cgi/content/abstract/85/1/95

I always get really worse on methylprednisolone. My mobility gets worse, my vision gets worse, fatigue and I get really crazy strong headaches.
So, it is not for me.
Erika