Re: Missing Link? Endothelin1 high in pwMS
Posted: Tue Jul 01, 2014 6:17 am
Mice and rat research on endothelin all use an endothelin anti-serumBillmeik wrote:Restoring CBF by interfering with the ET-1 system warrants further investigation as a potential new therapeutic target for MS.
k do.
http://www.ncbi.nlm.nih.gov/pubmed/8403065
This could be used to lower ET-1 in humans, if it were tested.On the rat RDS model produced by intravenous injection of oleic acid, , it was for the first time found that endothelin (ET) level in bronchoalveolar lavage fluid was elevated by 3-fold: and that preadministration of ET-antiserum to rat with RDS significantly improved its hypoxemia, pulmonary edema and histologic injury; inhibit the leakage of protein and intracellular enzymes from alveoli. The results suggest that ET might play an important role in the pathogenesis of RDS, and that treatment against ET would be a new approach for RDS.