This Is MS Multiple Sclerosis Knowledge & Support Community

http://www.reuters.com/article/2008/01/ ... 5220080108

Low dose daily Cialis. (Otherwise it's 8 pills a month, with most prescription plans.)

Daily would be more consistent, for sustained blood flow to the brain.



If your brain is, ahem, for more than four hours, please seek medical attention.

I posted this a while back about a study that shows Viagra increases the permeability of the Blood Brain Barrier, which I don't think would be too advantageous to PwMS.

http://www.thisisms.com/ftopict-12210-viagra.html

Thank you for re-posting that. I guess that would probably be a bad thing for us, but then again if the BBB is already being breached, then maybe wouldn't matter much.

There are apparently others. Levitra is one good one.

Has anyone given low dose Cialis a try?

if so what changes did you notice?

what about Male Enhancement Drugs, like Extenzes?

viagra should work on women right for increased blood flow ?

bump


anyone tried low dose viagra for post CCSVI ballooning?

.. and what about L-argine? It is quite commonly used by athletes and men with erection problems use it. It helps with Nitric oxide production in veins and there are many studies about it.. mostly with lab-rats, like this:

http://www.ncbi.nlm.nih.gov/pubmed/12614590

"L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats"
--> These studies support the theory that L-arginine administration improves post-traumatic cerebral blood flow by increasing NO production

PS. and some info in livestron.com "L-Arginine Effects on the Brain"

http://www.livestrong.com/article/37913 ... the-brain/

I have definitely noticed a difference in balance and mobility 'the day after' V. I am going to request the daily does of cialis from my doc this week and do my own study.

jay123 wrote:I have definitely noticed a difference in balance and mobility 'the day after' V. I am going to request the daily does of cialis from my doc this week and do my own study.

Lucky you! Hope it continues to work for you. Anything that can help us!

VIAGRA MAY BE NEUROPROTECTIVE & REDUCE MS SYMPTOMS
Seemed to be good for mice with EAE who were given it for 8 days. Details in press release from UAB:
http://www.uab.es/PDF/PDF_1306480140723_en.pdf
No info on dose. If action is neuroprotective may work in females. Applies to similar (PDE5) drugs.

MarkW

has any other men tried Cialis on a daily casis?

what daily dose? what results did you notice?

i am going to start a 2 week trial of cialis but not sure of what dose?
also what risks am i taking by using a daily dose of cialis for 2 weeks?

thanks

dc10 wrote:...also what risks am i taking by using a daily dose of cialis for 2 weeks?
thanks

Two weeks of non-stop headache seems like a heavy price to pay for whatever benefit you may achieve. But, good luck.

I suppose not everyone gets a headache from cialis, but many do. I don't know if this side effect is dose-dependent, but I'd read up on potential side-effects of cialis if I were you.

--Tracy

Ernst wrote:.. and what about L-argine? It is quite commonly used by athletes and men with erection problems use it. It helps with Nitric oxide production in veins and there are many studies about it.. mostly with lab-rats, like this:

http://www.ncbi.nlm.nih.gov/pubmed/12614590

"L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats"
--> These studies support the theory that L-arginine administration improves post-traumatic cerebral blood flow by increasing NO production

PS. and some info in livestron.com "L-Arginine Effects on the Brain"

http://www.livestrong.com/article/37913 ... the-brain/

I've been looking into L-Arginine as a potential supplement. What I find worisome is that Viagra and L-Arginine increase nitric oxide - though through different mechanisms.

NO has a role in several features of the disease, including disruption of the blood—brain barrier, oligodendrocyte injury and demyelination, axonal degeneration, and that it contributes to the loss of function by impairment of axonal conduction

http://www.thelancet.com/journals/laneu ... 3/abstract

And, from the same article:

However, despite these considerations, the net effect of NO production in MS is not necessarily deleterious because it also has several beneficial immunomodulatory effects. These dual effects may help to explain why iNOS inhibition has not provided reliable and encouraging results in animal models of MS, but alternative approaches based on the inhibition of superoxide production, partial sodium-channel blockade, or the replacement of lost immunomodulatory function, may prove beneficial.

I notice that some (human) users of l'arginine report reduction in fatigue.