can ccsvi explain these?
Posted: Sun Jun 05, 2011 6:17 pm
J R Soc Med 2005;98:303-306
Multiple sclerosis: looking beyond autoimmunity
Abhijit Chaudhuri PhD FRCP 1 Peter O Behan DSc FRCP 2
great paper, well worth a read: http://tinyurl.com/6jxo78e
Multiple sclerosis: looking beyond autoimmunity
Abhijit Chaudhuri PhD FRCP 1 Peter O Behan DSc FRCP 2
These are ten things about MS that cannot be explained by the autoimmune theory. How many can be explained by CCSVI? I am hoping for all ten.Box 1 Important facts about MS that cannot be explained by the concept of myelin-specific autoimmunity
Age effect of migration
Geographic variation (higher prevalence in most northern latitudes)
Maternal contribution to disease risk (Ref. 5)
Early and extensive grey matter involvement (estimated number of deep grey matter lesions per gram wet weight is higher than in any other brain structure [Ref. 6])
Progressive brain and spinal cord atrophy, beginning at the stage of clinically isolated demyelinating syndromes (Ref. 7)
Selective anatomical localization, symmetry and sharp margins of plaques
Absence of specific immunological marker
Effect of stress
General failure of immunotherapies that are highly successful in other organ-specific autoimmune diseases and transplant rejection
Associations with Charcot-Marie-Tooth disease and neurofibromatosis-1 (Ref. 2)
great paper, well worth a read: http://tinyurl.com/6jxo78e