DRUG ELUTING BALLOONS/CLINICS of the HEART/CABOS SAN LUCAS
Posted: Mon Aug 08, 2011 10:19 am
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Do you have a link to that paper?MarkW wrote:Hello Dania,
You are misquoting Zamboni. CCSVI is a syndrome not the cause of MS, please read his recent paper.
MarkW
It may be that CCSVI is best described as a syndrome. It may be that it will end up being causally linked with MS, with specificity and sensitivity. Because of the difficulties with determining how accurate the diagnostic imaging is, we need better research before we know which way it goes. For now it does seem safest to not talk about CCSVI as cause or cure for MS but as a syndrome. It is easier to agree upon that too, if I understand the definition of syndrome correctly.MarkW wrote:Hello Dania,
You are misquoting Zamboni. CCSVI is a syndrome not the cause of MS, please read his recent paper.
I would agree with this.You also talk about restenosis but did not provide evidence that a successful destenosis was performed. I would need to see IVUS data after the procedure to be convinced.
I would agree with this too.Until there is sufficient evidence that any ballooning technique is properly agreed I would not recommend stents nor drug eluting stents. We should be conservative in our approach and do some basic research.
MarkW
Mark, I don't know what to say? I never thought of it that way. If I do not put a comment, I support it? I neither support this or not. I do not know enough about it. I just like to share things I find. Just like I posted REGROWING BLOOD VESSELS. People who read it can make up their own minds what they think about it.MarkW wrote:Hello Dania,
If you post a site without comment you appear to support it. If you are not giving an opinion then please say so. There is a lot of mis-information being posted on CCSVI I and others try to challenge this on this site when we see it.
MarkW
Why don't you guys give Dania a break, already. And who are you to tell people how they should post anything? Dania simply posted and then linked an interesting article.MarkW wrote:Hello Dania,
If you post a site without comment you appear to support it. If you are not giving an opinion then please say so. There is a lot of mis-information being posted on CCSVI I and others try to challenge this on this site when we see it.
MarkW
It seems the whole point of this article is about a method providing some of the advantages of the drug-eluting stents, while only performing the ballooning (i.e. no stent is used).That’s why very recently a new therapeutic era has emerged with the advent of the Drug Delivering Balloons. This balloons have a substance capable of attaching to them the medication (Paclitaxel) but releasing it and adhering it to the contact surface during inflation inside of the artery. So after treatment and balloon deployment there is only the medication acting for a short period of time just to avoid the acute inflammation and later the artery is totally free from any foreign substance.
Very recently this same technology has been applied to large balloons to treat the arteries in the legs while reducing the restenosis rate and consequently the need for subsequent dilation treatments, with the benefit of minimal stent placement.
There are several successful trials with such balloons that were so conclusive that they justified their approval by the European regulations as well as their release into the market.
We have been using the Paclitaxel Eluting Balloons (Dior, Freeway) for more than one year with great efficacy and no complications.
?Moreover, the absence of Doppler and venographic features of CCSVI in controls suggests that venous obstructions may be causative of MS rather than a coincidental finding.
I am confused by this statement. Paclitaxel binds to microtubules and stabilizes them. This induces their polymerization. Microtubules are normally dynamic. However, once stabilized by Paclitaxel, they cannot reorganize into the spindle apparatus. This would block cell division and would be a useful method for inhibiting intimal hyperplasia, excessive cellular growth, as previously indicated.CD wrote:Dr. Siskin gave me tPA on a balloon catheter when I restenosed. It's a drug that breaks up clotting and helps the vein heal after clotting and before stent placement for added adhesion.
It is very much the same as Paclitaxel is for clot disolving
You are correct NHE, thanks for bringing this to my attention. They are not the same drugs or have the same method of action.NHE wrote:I am confused by this statement. Paclitaxel binds to microtubules and stabilizes them. This induces their polymerization. Microtubules are normally dynamic. However, once stabilized by Paclitaxel, they cannot reorganize into the spindle apparatus. This would block cell division and would be a useful method for inhibiting intimal hyperplasia, excessive cellular growth, as previously indicated.CD wrote:Dr. Siskin gave me tPA on a balloon catheter when I restenosed. It's a drug that breaks up clotting and helps the vein heal after clotting and before stent placement for added adhesion.
It is very much the same as Paclitaxel is for clot disolving
NHE