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Flavonoid Permeability across the Blood-Brain Barrier
The blood-brain barrier (BBB) is mainly formed by brain capillary endothelial cells, however other cell types such as pericytes, astrocytes and neuronal cells also play an important role [25]. Brain capillary endothelial cells differ from peripheral endothelial cells as brain endothelial cells have tight junctions which prevent paracellular transport of small and large water-soluble compounds from blood to the brain [25]. Transcellular transport is further limited due to low vesicular transport and high metabolic activity. Altogether, the BBB functions as a physical and metabolic barrier [25]. A prerequisite for CNS activity is therefore that flavonoids and their conjugates are able to traverse the BBB and enter the CNS.

Cognition and Neurodegeneration
Evidence is mounting that flavonoids have effect on memory, cognition and neurodegeneration. Although many of the studies in this field have been performed with flavonoid-rich fruits, both these studies and studies with isolated flavonoids indicate that flavonoids have potential to protect neurons against injury induced by neurotoxins and neuroinflammation, a potential to activate synaptic signalling and an ability to improve cerebrovascular blood flow, as has recently been reviewed [64].

Bethr wrote:I've just purchased a Bioflavonoid Complex tablet, with Hesperiden 280mg and Rutin 50mg
from a local health shop. Diosmin is apparently a derivative of hesperiden anyway.
I'll give it a go, two a day, and up my coloured fruit & veg also.
Seems a pretty natural thing, worth a try.
My Dr doesn't have a clue on these types of supplements!

Bethr wrote:
A bit of an update here. I'm still taking the hesperidin/rutin and a week ago I gave up
smoking also (35 year habit). I've been sleeping so well, and having really vivid, movie length dreams
every single night. I've suffered from interrupted sleep since this all started four years ago.
Amazing results though, I'm sleeping around 8 hours straight a night.
Overall I feel great. I've never been able to give up smoking before, I've tried many times. but I just feel so calm about it all this time. In fact I feel more calm in general since the iron reduction.

Trent wrote:I have been taking Diosvein 1 cap 3x/day for 10 days to help circulation, but no effect.
CCSVI had no effect either on my frozen legs/purple feet. Any ideas?

Trent wrote:I have been taking Diosvein 1 cap 3x/day for 10 days to help circulation, but no effect.
CCSVI had no effect either on my frozen legs/purple feet. Any ideas?