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Here is some very interesting information on a newly discovered hormone named Irisin. Some are suggesting possible implications for neurodegenerative conditions as well....very interesting.

http://www.ncbi.nlm.nih.gov/pubmed?term=irisin

http://www.nature.com/nature/journal/va ... 10777.html

http://scienceblog.com/51556/scientists ... rn-energy/

The scientists said their findings merely scratch the surface of irisin’s multiple effects. They are continuing to explore the hormone’s possible benefits in metabolic diseases like diabetes, insulin resistance, and obesity, which constitute a growing epidemic around the world, as well as neurodegenerative illnesses like Parkinson’s disease.
Spiegelman added that as growing evidence implicates obesity and physical inactivity in cancer development, it’s conceivable irisin-based drugs may have value in prevention and treatment of the disease.

Nature. 2012 Jan 11. doi: 10.1038/nature10777. [Epub ahead of print]

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.

Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA.

Abstract
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.

PMID:
22237023
[PubMed - as supplied by publisher]

Of course, there is no substitute for a proper diet and exercise when possible.

just a heads up iris in has been talked about here for years now, and it is mentioned in Zamboni's work.

Billmeik wrote:just a heads up iris in has been talked about here for years now, and it is mentioned in Zamboni's work.

When I did a "search" for the term, the only other posting here was by Lynda Carol, not too long ago.

http://www.thisisms.com/forum/post18477 ... in#p184770

I have no idea if it was mentioned by Zamboni.

I must be wrong.The chemical Im talking about is't a hormone and has something to do with iron.

It fits with the idea of metabolic dysfunction in MS, doesn't it?

2021 Aug 24
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Irisin levels in the serum and cerebrospinal fluid of patients with multiple sclerosis and the expression and distribution of irisin in experimental autoimmune encephalomyelitis
https://pubmed.ncbi.nlm.nih.gov/34428306/

Abstract

Irisin is a novel hormone-like myokine that plays an important role in central nervous system (CNS) diseases, such as cerebral ischaemia and Alzheimer's disease. However, irisin is rarely investigated in multiple sclerosis (MS), a typical inflammatory demyelinating disease of the CNS, and in experimental autoimmune encephalomyelitis (EAE), a typical model of MS. We determined the levels of irisin in the serum and cerebrospinal fluid in patients with MS. The expression and histological distribution of irisin were determined in EAE. Serum irisin levels in patients with MS and in EAE mice were increased, and the levels of FNDC5/irisin mRNA were decreased in the spinal cord and brain regardless of the onset, peak or chronic phase of EAE. Immunofluorescence staining showed colocalization of irisin and neurons. The levels of irisin fluctuated with disease progression in MS and EAE. Irisin may be involved in the pathological process of MS/EAE.