Re: Wall shear stress:the missing step for Tcell transmigrat
Posted: Thu Apr 12, 2012 4:11 pm
Newbie lurker and this discussion is way over my head but wayback in the 70s I did my undergrade Co-op at NIH and we were modeling blood shear rate changes at the endothelial walls as it relates to aethrosclerotic plaque build-up. Mostly in the bifurcations at the celiac and superior messinteric(sp) branches. With constant shear cells stayed in alignment with each other but when you ate a big meal or other activity the blood flow ratios changed and cells would become misaligned with each other causing gaps which allowed initial calcification etc. Not sure where that research ever ended up as I went off on a life long non medical field tangent. Perhaps similar mechanism exists albeit simplistic to your discussion.
We had really cool laser dopler anemometers and dye injection flow visualization techniques to give the velocity profiles as blood flow ratios changed.
You know when I trout fish I look for a rock in the middle of a stream and fish the eddy behind it.
We had really cool laser dopler anemometers and dye injection flow visualization techniques to give the velocity profiles as blood flow ratios changed.
You know when I trout fish I look for a rock in the middle of a stream and fish the eddy behind it.