abstracts for 2013 AAN
Posted: Sun Feb 17, 2013 7:33 pm
http://www.aan.com/go/homeAbstracts for the 2013 AAN Annual Meeting Scientific Program are now available to view online.
Could this help pwCCSVI as well? It's botox delivered to the facial, scalp and neck muscles. This led to a reduction in intracranial vascular resistance in migraine patients.[P01.085] Evaluation of Cerebral Hemodynamics of Patients with Chronic Migraine: Effects of the Botulinum Neurotoxin-A
Hakan Akgun, Ankara, Turkey, Serdar Tasdemir, Ankara, Turkey, Mehmet Yucel, Istanbul, Turkey, Oguzhan Oz, Ankara, Turkey, Umit Ulas, Ankara, Turkey, Seref Demirkaya, Ankara, Turkey, Yasar Kutukcu, Ankara, Turkey
OBJECTIVE: Migraine is a neurovascular disorder. Change in the diameter of intracranial arteries is thought to be an important underlying mechanism in migraine pathophysiology. Transcranial-Doppler-Ultrasound (TCD) is a non-invasive method to evaluate intracranial vascular system. Recent studies showed that botulinum neurotoxin-A (BoNTA) is an effective treatment choice in migraine headache. BACKGROUND: We aimed to evaluate the changes in middle cerebral artery (MCA) and posterior cerebral artery (PCA) in terms of Mean Blood Flow Velocity, Breath-Holding-Index (BHI) and pulsatility index (PI) in patients with chronic migraiene before and after treatment with BoNTA by using TCD. DESIGN/METHODS: The study included 25 patients with chronic migraine. 12 patients were treated with high-dose (100 IU) BoNTA and 13 patients were treated with low-dose BoNTA (50 IU). BoNT was injected to facial, scalp and neck muscles. Mean blood flow velocity, BHI and PI were measured before and 7 days after BoNTA injection in MCA and PCA bilaterally in both groups. We compared the pre-treatment and post-treatment values. We also evaluated the Visual Analogue Scale (VAS) scores in both groups before and after-treatment. RESULTS: Pulsatility index was significantly decreased in MCA (before treatment PI=0,74±0,13, after treatment PI=0,69±0,10) (p=0.024) and insignificantly changed in PCA after treatment in high-dose group (p>0.05). Differences in Mean blood flow velocity and BHI were insignificant in both groups in both arteries (p>0.05). VAS scores significantly decreased after treatment in both groups (p<0.001). CONCLUSIONS: The PI is a well known indicator of peripheral vascular resistance. Our results suggest that BoNTA treatment may be effective by reducing the resistance in intracranial vascular beds in patients with chronic-migraine.
Category - Headache: Therapeutics
http://www.abstracts2view.com/aan/view. ... 3L_P01.085