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Randomized Trial of Immediate versus Delayed Transluminal Percutaneous Angioplasty to treat Chronic Cerebrospinal Venous Insufficiency

Would interested participants consider enrollment if there was the possibility of a 6 month delay in their treatment for CCSVI?

All participants would receive treatment and all symptoms tracked pre- & post-procedure at 1 month intervals for 1 year. This seems more reasonable from a vascular perspective, but this is not a drug trial design. I don’t believe the treatment of TOS via PTA would have a sham treatment arm. Of course, this has been discussed at length many times. The delayed treatment interval could be reduced to 3 months.

NO, Dr. Siskin. Now is not the time to lower your scientific standards. If you say, it's OK, it's time to retire from this, you are giving up, and the Forces of Ignorance have won. The only way to win is to play, on a level field. The rules are strict, but you are setting yourself up to fail if you just pack up and go home when you have a setback. That is what the Fool and Dunce Admiseration are handing you, and you must fend off these minor blows. Sham procedures, randomization etc., are why you get the big bucks to do research. They are not rocket science either. The trial is ready to go. It just needs a few brave American women and men to step up. I know they will. Let them. I am willing to put some of my few dollars into it, and I bet there are plenty of others of the same mind.

I gave $100 or $200, once only, to McMaster for Dr. Haake's research, and I expect to receive begging letters and phone calls for the rest of my life. If they can do it, so can you. Appeal to existing patients and previous ones. Appeal to the caregivers of MS/CCSVI patients, too.

The more people that get put down without any response, the harder it will be for the next one to carry the torch when you do want to pass it. CCSVI is winning this race, except where interference from drug vendors and lobbyists is allowed to prevail.

Listening to the Saskatoon papers (or the FDA) about heavy scientific or ethical matters is like listening to your cat tell you what you should have for dinner, or how to drive your car.

If you do revisit the design of your trial, you might want to include the use of IVUS.

Sask. MS patient wants liberation therapy answers after trial cancelled

Read more: http://regina.ctvnews.ca/sask-ms-patien ... z2esSWDB16

pairOdime wrote:Randomized Trial of Immediate versus Delayed Transluminal Percutaneous Angioplasty to treat Chronic Cerebrospinal Venous Insufficiency

Would interested participants consider enrollment if there was the possibility of a 6 month delay in their treatment for CCSVI?

All participants would receive treatment and all symptoms tracked pre- & post-procedure at 1 month intervals for 1 year. This seems more reasonable from a vascular perspective, but this is not a drug trial design. I don’t believe the treatment of TOS via PTA would have a sham treatment arm. Of course, this has been discussed at length many times. The delayed treatment interval could be reduced to 3 months.

there are patients who have delayed onset of some improvements up to one year after treatment. While they had improvements in the early term, other improvements did not show until 11 months or later.

DrS