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Regulatory T cells (Tregs), which are induced locally in the skin-draining lymph nodes in response to UVB exposure, connect the cutaneous immune response to CNS immunity by migration to the sites of inflammation (blood, spleen, CNS). Here, they attenuate the inflammatory response and ameliorate disease symptoms.

cheerleader wrote:The sun is free. No prescription needed.
10-15 minutes of sunshine or UVB phototherapy sends Treg cells flowing from the lymph nodes to sites of inflammation in people with MS. People with MS had symptom relief in a study completed by German neurologists and published last week.

Regulatory T cells (Tregs), which are induced locally in the skin-draining lymph nodes in response to UVB exposure, connect the cutaneous immune response to CNS immunity by migration to the sites of inflammation (blood, spleen, CNS). Here, they attenuate the inflammatory response and ameliorate disease symptoms.

Why the skin releases healing T cells when exposed to UV--
as Dr. Richard Weller's research is showing is, it's thanks to nitric oxide.
http://ccsviinms.blogspot.com/2014/04/m ... mptom.html
cheer

cheerleader wrote:Glad you had the Spanish adventure, Mark!
As Dr. Weller discusses in his TED talk, you don't get the same thing from vitamin D---It's the way the UV rays release nitrates from our skin, and this in turn releases Treg cells from lymph nodes. Has to be rays from the sun or a special lamp via dendritic cells. All new research.
Check out his talk---he's a very funny and entertaining scientist, I think you'll appreciate!

best,
cheer

Donnchadh wrote:Interesting. Yesterday I had to wait outside for about a half hour for my Postmaster to arrive. Here in northern Illinois,
it was the first day over 70 degrees and sunny. Usually, I rarely go outside.

Today, my symptoms were a little bit better and I couldn't figure out why.

It might have been due to the sunshine?

Donnchadh

We found that all-cause mortality was inversely related to sun exposure habits in a ‘dose- dependent‘ manner. The mortality rate was increased two-fold among avoiders of sun exposure as compared to those with the highest sun exposure habits.

We conclude that women who avoid sun exposure are at an increased risk of all-cause death with a two-fold increased mortality rate as compared to those with the highest sun exposures. The implementation of restrictive sun exposure advice in countries with low solar intensity might not be beneficial to women’s health.

A number of prescription drugs, too, can deplete B12 stores, particularly in older patients. Among the most common are proton pump inhibitors, metformin (Glucophage), H-2 blockers, antacids, anticonvulsants, some antibiotics, and colchicine. Nitric oxide and other nitrates (nitroprusside) oxidized B12 and may also induce deficiency. In young and middle-aged women, birth control pills are a common culprit.

I get this question a lot. Thought I'd take the time to break it down in English (as opposed to chemistry talk, which still makes my head spin.)

Nitric Oxide (NO) is NOT the same as Nitrous Oxide (N2O).
Nitric Oxide is one molecule of nitrogen, one of oxygen.
Nitrous Oxide has 2 molecules of nitrogen, and one of oxygen.
And that extra molecule of nitrogen changes the gas completely.

Nitrous Oxide (N2O) has been getting some press recently, since Demi Moore was hospitalized for inhaling canned Nitrous Oxide (in a form called "whippets") and having a seizure. Nitrous oxide is used in aerosol cans, to propel whipped cream or cooking spray out of the bottle.

Nitrous Oxide (N20) is what they give you at the dentist's office....also called "laughing gas." I had my wisdom teeth out on Nitrous Oxide, and it made me so loopy, I was laughing while the oral surgeon was sawing into my jawbone to remove my impacted wisdom teeth. It's powerful stuff. And should not be used recreationally.

What I started writing about and investigating for Jeff's health was endothelially derived nitric oxide or eNOS, which is made inside your own body

cheerleader wrote:Hi Lynda--
That quote confused "nitric oxide" with "nitrous oxide."
Two completely different things. One is an external drug and one is made by our bodies.
I've written about this before--

I get this question a lot. Thought I'd take the time to break it down in English (as opposed to chemistry talk, which still makes my head spin.)

Nitric Oxide (NO) is NOT the same as Nitrous Oxide (N2O).
Nitric Oxide is one molecule of nitrogen, one of oxygen.
Nitrous Oxide has 2 molecules of nitrogen, and one of oxygen.
And that extra molecule of nitrogen changes the gas completely.

Nitrous Oxide (N2O) has been getting some press recently, since Demi Moore was hospitalized for inhaling canned Nitrous Oxide (in a form called "whippets") and having a seizure. Nitrous oxide is used in aerosol cans, to propel whipped cream or cooking spray out of the bottle.

Nitrous Oxide (N20) is what they give you at the dentist's office....also called "laughing gas." I had my wisdom teeth out on Nitrous Oxide, and it made me so loopy, I was laughing while the oral surgeon was sawing into my jawbone to remove my impacted wisdom teeth. It's powerful stuff. And should not be used recreationally.

What I started writing about and investigating for Jeff's health was endothelially derived nitric oxide or eNOS, which is made inside your own body

Yes, nitrous oxide will deplete B12---people who abuse "laughing gas" have this problem.
https://www.karger.com/Article/FullText/353623
http://jama.jamanetwork.com/article.asp ... eid=403433

They also mention nitroprusside, which is an external, pharmacological form of NO---again, NOT the same as eNOS.
Nitric oxide, which is made by our bodies and derived from our own endothelial cells (eNOS)--is a good guy. It actually helps with B!2 absorption. It must remain eNOS (the e is for endothelial), and not collect anymore oxidative molecules (from smoking, high blood pressure, high glucose)--because that changes eNOS and makes it an oxidative stressor. A healthy lifestyle will keep all in balance. And UV rays are part of this.
http://www.ncbi.nlm.nih.gov/pubmed/23363713
http://groups.csail.mit.edu/sls/publica ... -02492.pdf
Hope that explains it better!
cheer

lyndacarol wrote:I have always thought the sun was good for us. I have tried to soak up the sunshine for 10-15 minutes per day. I thought nitric oxide was the key – a positive. And yet, I become very weak (a "noodle") after my time in the sun (without even raising my body temp).

Cece wrote:

lyndacarol wrote:I have always thought the sun was good for us. I have tried to soak up the sunshine for 10-15 minutes per day. I thought nitric oxide was the key – a positive. And yet, I become very weak (a "noodle") after my time in the sun (without even raising my body temp).

It's 100% not related to body temp? If you are drinking ice water, it still happens?

cheerleader wrote:What I started writing about and investigating for Jeff's health was endothelially derived nitric oxide or eNOS, which is made inside your own body

In healthy blood vessels, eNOS-derived NO contributes to the regulation of blood flow and blood pressure, is an inhibitor of platelet activation and aggregation as well as leukocyte adhesion and migration [12]. Furthermore, endothelial eNOS appears to contribute to the formation of bioactive circulating NO metabolites [13], [14], [15], [16] and [17] (Fig. 1) that participate in important endocrine activities such as hypoxic vasodilation, blood pressure regulation, gene expression and cytoprotection following myocardial infarction [18], [19], [20], [21], [22], [23], [24], [25], [26] and [27]. Mice genetically deficient in endothelial nitric oxide synthase (eNOS-/-) are hypertensive and have lower circulating nitrite levels, demonstrating the importance of constitutively produced NO to blood pressure regulation and vascular homeostasis [14], [28], [29] and [30].