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Gladstone Institute research published in Nature shows that all it takes to create MS is one single drop of blood on brain tissue. You don't need a rogue virus, or auto-immune t cells.

Just a drop of blood.
http://ccsviinms.blogspot.com/2015/10/a ... blood.html

cheer

This is a huge breakthrough.

A major confirmation in Dr. Zamboni's theory that CCSVI can cause MS.

And it was funded in part by the National MS Society.

This is really great research.

Do any of them at UCSF know Dr. Zamboni? Didn't be study/work at UCSF?

Thank you for all of your posts.

And Rotary is so close to eliminating polio forever.

A great day.

Agree, Rogan.
This is huge. The Gladstone Institutes is independent and in Silicon Valley, although they work with local universities---(UCSF has actually been very anti-CCSVI research -due to the head of the program, Hauser, being a major proponent of ocrelizumab and other serious immune ablating therapies) Dr. Zamboni has ties to another northern CA institute, Stanford University, thru his graduate schooling and Dr. Michael Dake serving on the ISNVD.

This research is making huge waves right now. We finally have a better, more realistic MS mouse model. More correct than EAE, which required injecting foreign antigens into mouse brains. People with MS have microbleeds and blood deposits in their brains, as evidenced on 7T MRI---so we know this new model is accurate.

better days ahead,
cheer

Here is Dr. Yulin Ge's ground breaking research, showing the vascular wall changes and micro bleeds in the MS brain, at 7T MRI. alterations precede demyelination.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579786/

I was a little surprised to see this article was published back in 2008 (ie it took some time to be brought up, if it hasn't already). I also noticed one of the articles citing it may be of interest to you with lots of mentions on the endothelial and BBB etc. Although it is about 65 pages long and not so familiar with the journal it was published in.

That paper you linked is pretty funny, Cure--w/about 500 citations, it covers it all . Even Zamboni got a citation!

The Yulin Ge paper from 2008 has been on here before. No one commented.
http://www.thisisms.com/forum/general-d ... 19285.html
I've been a fan girl for awhile.

Here are some more threads mentioning Dr. Ge. I met him at 2014 ISNVD. He is a serious, well-funded scientist from NYU, who is convinced MS is vascular----he's been documenting the microbleeds which precede demyelination for many years. Maybe people will pay attention now? He'll be at ISNVD 2016 in New York.
http://www.thisisms.com/forum/chronic-c ... 24352.html
http://www.thisisms.com/forum/chronic-c ... 25492.html
http://www.thisisms.com/forum/chronic-c ... 25675.html


cheer

cheerleader wrote:The Yulin Ge paper from 2008 has been on here before. No one commented.
http://www.thisisms.com/forum/general-d ... 19285.html
I've been a fan girl for awhile.

So you just sit there and bide your time... waiting.... waiting to spring UP! and surprise us when the world is ready to start listening.

cheerleader wrote:... Dr. Ge. I met him at 2014 ISNVD. He is a serious, well-funded scientist from NYU, who is convinced MS is vascular----he's been documenting the microbleeds which precede demyelination for many years. Maybe people will pay attention now? He'll be at ISNVD 2016 in New York.

A little self centered I know, but does this well funded man have any ideas on correcting/resolving the issue?

Funny you should ask!
At the Canadian Neurovascular conference in Vancouver this weekend, and the discussion would interest you, Cure.
Lots of talk on cerebral microbleeds in MS, now being documented by Haacke and co. using SWI technology. And discussion of the Gladstone Institute research, which is really getting some attention. It's obvious that understanding the cause of these microbleeds is essential. We know what happens in TBI, concussion, stroke....but what's up with MS? Why the blood leaking along cerebral veins? Could it be Dr. Zamboni was right about venous hypertension? Is refluxive flow and increased intracranial pressure creating endothelial dysfunction/leaky blood brain barrier? Can repairing venous hemodynamics reverse this? More research ahead---but I think you know what I think. Dr. Yulin Ge is a member of the ISNVD, and thinks Zamboni is on to something, and we need more clinical trials of venoplasty. I do believe consensus is building.

As far as other treatment, more discussion on the endothelium from Dr. Bill Code-- and strengthening this barrier using nutrition, exercise, probiotics, antioxidants, stress reduction, B12 and vitamin D (hmmm...that sounded familiar!).

Yeah...I just sit back and wait for everyone else to catch on
I'll be writing up a blog post on the conference. Will post a link when it's up.
Time for sleep, early morning presentation tomorrow from Zamboni via skype.
cheer

The Yulin Ge paper from 2008 has been on here before. No one commented.
general-discussion-f1/topic19285.html
I've been a fan girl for awhile.

Like many of the MS-UK URLs you might see around here, this one is stale. Please post links to the original research, if you can still find it. I've commented on Dr. Ge's work. I'm very spoilt; I need a one-click link or I am instantly bored.

1eye wrote:Like many of the MS-UK URLs you might see around here, this one is stale. Please post links to the original research, if you can still find it. I've commented on Dr. Ge's work. I'm very spoilt; I need a one-click link or I am instantly bored.

Its a few posts above..

CureOrBust wrote:

1eye wrote:Like many of the MS-UK URLs you might see around here, this one is stale. Please post links to the original research, if you can still find it. I've commented on Dr. Ge's work. I'm very spoilt; I need a one-click link or I am instantly bored.

Its a few posts above..

OK, I'll bite. Dr. Ge had the unfortunate luck to be examining humans in vivo and not dead mice.

But now isn't it rather obvious that MS lesions are the result of venous blood leakage? Isn't that why gadolinium lights them up? Because it is carried there by blood, and some of the blood is leaking from central veins? I thought this was common knowledge. How many papers do we need to read before the penny drops? MS has had a lot of mystery in the past, but aren't we clued in yet?

Tell me about it. I said in 2008 that the leaks in the blood brain barrier looked like plasmic particles were entering the brain due to endothelial dysfunction, and posted lots of research.

The basic premise of the thread is this, MS is a disease of the circulatory system. The lining of the blood vessels (the endothelium) becomes damaged by stuff (toxins, free radicals, bacteria) and the blood leaks particles into the CNS and body, creating damage. Blood flow is slowed down, and for some, the blood itself thickens and coagulates.
Some people show varicose veins, some have reddish brown dots (like my hubby) we can see with the eye. I believe the damage we see on MRIs of people with MS is a breaking of the cerebral endothelium.

One click : http://www.thisisms.com/forum/regimens- ... c6318.html

If it was "common knowledge" that plasmic particles enter brain tissue, as they do--- MS patients would not be doing chemo or major immune ablating drugs---because that's not such a good idea w/a leaky cerebral endothelium and CNS immune system. But MS neuros continue the myth of EAE and a crazed immune reaction, while the research continues to point to a known immune reaction after a vascular event.
Stroke researchers publish on it.
One click: http://ccsviinms.blogspot.com/2010/12/t ... troke.html
But MS researchers ignore it.

Forgive the sarcasm, but after seven years of saying this at conferences, blogging, talking to researchers and posting on forums, I find the lack of patient interest in this area rather disheartening. Things don't change unless patients are educated and ask questions. I spent the weekend in Vancouver at the CNHS conference and heard speaker after speaker say it, discuss their publications and research...the vascular connection to MS is real and it precedes demyelination and neurodegeneration.
cheer

I wonder if the issue is a lack of patient interest. I agree there is more than “something” to the vascular system. So much so that I went to San Diego a few years ago and was treated. Since that time, my life has changed drastically for the better. It is the only thing that I have ever done that reversed the path of the disease. In my humble opinion anyway and everyone who knew me before MS, after, and post procedure. Those of us who have MS are treated by Neurologists and the rest of the medical establishment defers accordingly. Neuros have a grip on us and are not going to let go until there is overwhelming evidence. And even then, it will likely be others in the medical establishment that convince them it is time to let go. I recently had an appointment with my neuro. He commented, again, on how well I am doing. He was impressed that I now ride, bicycle and motorcycle, in 100 degree weather. I work outside in the same weather without being wiped out. He is well aware I have been treated but never asks about it. He normally does not down talk the theory knowing I am always primed for a fight. He threw a barb (a study that had been batted around here actually and roundly discredited) and as usual I pounced. I mentioned that since being treated I have been able to do things I never thought I would do again. That it was worth the 5G I spent on the procedure and that nothing that is considered the standard of care ever helped as far as I can tell. And he just looked amused and went on with whatever it was he was saying. There is little doubt in my mind that all of the improvement I have experienced is due to the procedure. Outside of what I have already done, that is, follow the research and get treated, what are we supposed to do? The medical establishment defers to neurologists. And they listen to no one that is not in their fold. And we MS patients pay the price, some more than others. I don’t lack interest as I sing praises to anyone who will listen. I am just not sure what else I can do beyond what I am already doing.

10yearsandstillkicken wrote: I don’t lack interest as I sing praises to anyone who will listen. I am just not sure what else I can do beyond what I am already doing.

Keep on keeping on. Glad to hear you're doing well, 10years!
Things you can do: Encourage other people with MS to live heart healthy lives. Keep your medical records on file, and share with all who will listen. Share the new research from Gladstone Instititute from the 1st post at the top w/your doctors. Invite your neuro to attend the ISNVD conference in April 2016 in NYC at the Academy of Sciences to learn more. http://www.isnvd.org

If one drop of blood can create the MS immune reaction, than the microbleeding researchers are seeing in the MS brain is enough to cause an immune reaction. We don't need a deranged "auto" immune theory. We need to look at why the blood brain barrier is being broken. Is it venous hypertension (too much pressure on those veins)? If so, your CCSVI venoplasty procedure may have relieved that, and allowed for healing. Is it endothelial dysfunction? If so, venous repair might have allowed for shear stress and healthy flow to heal those cells. But doctors can no longer say there is no vascular involvement in MS. It's simply not true.

cheer

The writing is on the wall. As always, I'll keep on promoting the story to anyone that will listen. It is tiring though. Its seems so clear that there is something to this and there is ample research that should be getting Neurologists attention. Shouldn't scientific curiosity, at the very least, get their attention? It's not like they have another theory that fits the bill. It has not been proven over many decades of looking. It is frustrating and disheartening. Chalk it up to life isn't fair I guess...