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Posted: **Wed Jun 10, 2009 6:13 am**

Preliminary report on pathologic flow patterns in the internal jugular and vertebral veins of patients with multiple sclerosis
Marian Simka, Jacek Kostecki, Maciej Zaniewski, Eugeniusz Majewski, Danuta Szewczyk-Urgacz
Phlebological Review 2009; 17(2):61-64
ICID: 887336
Article type: Original article
IC™ Value: 3.00

Multiple sclerosis is a chronic neurologic disease of undetermined background. Recent discoveries suggest that this disease could be a venous pathology. The study has been done to assess veins in the neck in multiple sclerosis patients, in order to confirm findings by researches from Ferrara. There were examined 8 patients with proven diagnosis of multiple sclerosis. They were performed color Doppler examination of their internal jugular veins and vertebral veins. Abnormalities were found in all patients, but no universal anatomical pattern of venous pathology existed. There were found: occlusion of one internal jugular vein - 2 patients, stenosis of one internal jugular vein - 4 patients, stenosis of both internal jugular veins - 2 patients, stiff but not yet narrowed internal jugular vein - 1 patient, reflux in internal jugular vein – 2 patients, stenosis of vertebral veins - 3 patients, reflux in vertebral veins - 1 patient. Although further studies are needed to establish the actual role for pathology of extracranial veins in the etiopathogenesis of multiple sclerosis, these investigations can open a new chapter in management of this debilitating neurologic disease.

ICID 887336

now available HERE

This is also added to the replicating studies thread...

Cheer posted an abstract of an earlier version of this paper some time ago but this is the official published version....hot off the press. The final version lost the reference to the 3 cases of probable MS who also showed this when tested and I have asked why, will post that response when we know... but it is very common for editors to as for revised papers so they may be responsible for that
marie

Posted: **Wed Jun 10, 2009 8:53 am**

I might be because maybe the probable MSers could look like controls as they have not been totally diagnosed yet. So people might question the 100% finding. (just my thoughts)

Posted: **Wed Jun 10, 2009 9:13 am**

LR My thought was similar like only include them once you know the final diagnosis result so they are NOT possibly "non MSers".

Bottom line though neurological problems to the point of probable MS and then a positive doppler findings in the light of Zamboni's findings is pretty remarkable. If all were eventually dix'd with MS it is important, maybe it'll be a separate paper down the road with fllow ups...

Posted: **Wed Jun 10, 2009 10:28 am**

so am i one of those 8 / which 1 / i wonder / the latest is they are recruiting 1100 people some w-ms and others not 2 compare /m STAY STRONG ALL ---P S --THE JOG 4 THE JAKE which is the big fundraisor on fathers day i will sniff around [ in the post race beer tent ] all the big shots will be there

Posted: **Wed Jun 10, 2009 11:27 am**

Is that Jacob's field in Cleveland?

Posted: **Wed Jun 10, 2009 12:05 pm**

It would be interesting to know why they were considered probable MS'rs -i.e. lesions, neurological testing.

Posted: **Wed Jun 10, 2009 12:18 pm**

it s the jacobs neurological institute in buffalo

Posted: **Wed Jun 10, 2009 12:59 pm**

The answer on the three probable MSers was that the data set was too small to be useful for significance, so it was elimated.

The final version lost the reference to the 3 cases of probable MS who also showed this when tested and I have asked why, will post that response when we know

Posted: **Wed Jun 10, 2009 1:13 pm**

Thanks for posting, Marie.
I like the fact that Dr. Simka refers to it as abnormalities of the extracranial veins. This opens up the doppler scanning process of CCSVI to consider how reflux in all of the surrounding veins can signal a problem.

Dr. Simka needs to test more "probable MS" patients and controls and get a larger sample for another paper. This is a very important connection to the beginnings of MS.
Thanks for all your time and effort Dr. Simka!!!
cheer

This Is MS Multiple Sclerosis Knowledge & Support Community

Simka's latest!!

Simka's latest!!

hi marie