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Zamboni's new paper- Venous Collateral Circulation 8/09
Posted: Fri Aug 07, 2009 3:48 pm
by cheerleader
the plot thickens....
Collateral Circulation in CCSVI
Abstract: A new nosologic vascular pattern that is defined by chronic cerebrospinal venous insufficiency (CCSVI) has been strongly associated with multiple sclerosis. The picture is characterized by significant obstacles of the main extracranial cerebrospinal veins, the jugular and the azygous system, and by the opening of substitute circles. The significance of collateral circle is still neglected. To the contrary, substitute circles are alternative pathways or vicarious venous shunts, which permit the drainage and prevent intracranial hypertension. In accordance with the pattern of obstruction, even the intracranial and the intrarachidian veins can also become substitute circles, they permit redirection of the deviated flow, piping the blood towards available venous segments outside the central nervous system. We review the complex gross and radiological anatomy of collateral circulation found activated by the means of EchoColor-Doppler and selective venography in the event of CCSVI, focusing particularly on the suboccipital cavernous sinus (SCS), the condylar venous system, the pterygoid plexus, the thyroid veins, and the emiazygous-lumbar venous anastomosis with the left renal
vein.
Posted: Fri Aug 07, 2009 4:22 pm
by catfreak
Hey Cheer,
I could not open the link.
Cat
Posted: Fri Aug 07, 2009 4:38 pm
by peekaboo
me too
Posted: Fri Aug 07, 2009 9:34 pm
by bibliotekaren
Posted: Sat Aug 08, 2009 5:14 am
by catfreak
Thanks, it works now!!
Cat
Posted: Sat Aug 08, 2009 6:29 am
by gibbledygook
Now that's a paper to get one's mental teeth into!!! Great find Cheereo.
Posted: Sat Aug 08, 2009 6:33 am
by peekaboo
You not kidding Gibbs....Thanks Cheer
my MRV shows a portion of my intercranial veins occluded. it will be interesting to find out if it is the same or changed due to the azy and jug stents on the 13/14th for my follow up
H
Posted: Sat Aug 08, 2009 7:10 am
by catfreak
Man, I only wish I understood all of this. I mean I understand the concept but...... WOW!
If it weren't for the researchers here, thank you all!! I would not know anything about anything without all of you and TIMS.
I don't want to be one of those MS patients who lets Big Pharma rule my life.
On another note:
I had to go to my GP thursday with a UTI which I am told is one side effect of the Tysabri infusions, I talked to him about me coming there to get my blood testing non after intervention.
He wanted Dr D's name and wants to research the CCSVI. I am going to take him of these Zamboni papers and any other stuff I can find.
I am also going to give him Dr D's email since I am sure he will have questions.
Cat
Posted: Sat Aug 08, 2009 8:38 am
by mrhodes40
That is a great paper for this model it goes into the research page for sure.
This work fleshes out the earlier work in another direction in that it outlines the actual pathology rather than simply establishing the association.
Note also the thyroid vein collateral circle, and remember that the only autoimune disease really associated with MS is thyroid disease both graves (high thyroid) and sometimes hashimoto's.
In the Campath trial people are getting graves very often, like 30% of the time. Is it possible the continual battering of the thyroid by the venous back pressure while also suffering from a severely altered immune system is allowing this situation to develop? I wonder....
http://www.jci.org/articles/view/37878