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New paper online today-
Dr. Haacke collaborates with Dr. Reichenbach in Jena, Germany-

Multiple sclerosis with the CCSVI protocol: SWI, MRA and FQ

Case 1 of the NICE protocol as proposed by the MRI Institute for Biomedical Research

The first complete case we studied came from a collaboration with Juergen Reichenbach in Jena, Germany.

This patient was 45 years old and had a full brain susceptibility weighted imaging scan, an MR venogram of the major veins in the head and neck, and flow quantification in the jugular and dural sinuses.

Here are some example images showing the iron in the lesions from SWI, the iron in the basal ganglia, a conventional FLAIR image, and an image showing the stenosis of one jugular vein.

Figure 1: a) SWI filtered phase image of the basal ganglia in this patient showing abnormal iron content in the globus pallidus on both sides of the brain. b) SWI filtered phase of a normal volunteer showing only vessels no iron build up. c) SWI through the same region showing the main
thalamostriate venous drainage system.

Figure 2: a) Conventional FLAIR image showing a variety of lesions around the ventricles.
b) A single slice SWI filtered phase image showing iron in some lesions and a ring of iron around
one lesion not clearly seen at all with the FLAIR image.

Figure 3: pinched jugular vein

to see the pics, go to
http://www.ms-mri.com/cases/1.pdf

Looks like doctors are using Dr. Haacke's new protocol to diagnose CCSVI. He will be putting the cases up on line as they come in-
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Wow, that is so cool!

Agree, Rokkit! What's really cool is seeing how a crimped jugular vein creates reflux of blood which leads to iron deposition in the MS brain...just like Dr. Zivadinov, Dr. Zamboni, Dr. Salvi, Dr. Haacke, Dr. Schelling and others have stated it does. These pictures will be worth a 1,000 words, and should help speed diagnosis and treatment for MS patients.

Dr. Juergen Reichenbach is participating in this study at the University of Jena, Germany...for our German friends.

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also new on Dr. Haacke's site:
SWI/MRI/MRV collaborative sites that are participating in his MS protocol study-
Alexander Rauscher
UBC High Field Magnetic Resonance Imaging Centre, M10 Purdy Pavilion
2221 Wesbrook Mall, Vancouver V6T 2B5, CANADA
(604) 827-5462
(604) 827-3339

Derek Emery, MD, FRCPC
University of Alberta, Dept. of Radiology and Diagnostic Imaging
2A2.42 Walter C Mackenzie Health Science Center, Edmonton, Alberta, T6G 2B7, CANADA
(780)407-6907
(780)407-1202

Katherine Knox, MD, FRCPC
Saskatoon City Hospital
701 Queen Street S7K 0M7, CANADA
(306)655-8447
(306)655-8404

J. Kevin DeMarco, MD
Michigan State University
184 Radiology Building, East Lansing, MI 48824, USA
(517) 355-0120
(517) 432-2849

James Garbern
Dept. of Neurology, 8A University Health Center
4201 St. Antoine, Detroit, MI 48201, USA
(313) 745-4275
(313) 745-4468

Jonathan Grynspan, MD, FRCP(C)
33 University Suite, Apt 2104,
Toronto Ontario M5J 2S7, CANADA
(905) 577-9392
(905) 529-0268


Juergen Reichenbach, PhD
Institut fur Diagnostische und Interventionelle Radiologie, Universitatsklinikum Jena
MRT-Gebaude Am Steiger, Philosophenweg 3, D-07743 Jena, GERMANY
+49-36-41935372
+49-36-41936767

Haibo Xu, MD
Dept. of Radiology, uni0n Hospital, Tongji Medical College
Huazhong Univ. of Science and Technology, 1277 Jiefang Ave, Wuhan, Hubei 430022, CHINA
+86-27-85726410
+86-27-85776343

Kohsuke Kudo, MD
Advanced Medical Research Center, Iwate Medical University
19-1 Uchimaru, Morioka 020-8505, JAPAN
+81-19-6515111
+81-19-6221091

Satoshi Terae, MD, PhD
Dept. of Radiology, Hokkaido University Hospital and Graduate School of Medicine
N15 W7, Kita-ku, Sapporo 060-8638, JAPAN
+81-11-7065977
+81-11-7067876

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Amazing images! It's pinched to almost nothing..Cool to see though.
Wonder if that's a severe case, or the norm of severity in people w/ms?

sewwhat wrote:Amazing images! It's pinched to almost nothing..Cool to see though.
Wonder if that's a severe case, or the norm of severity in people w/ms?

That's what my hubby's left jug looked like...pinched 95% closed with lots of little collaterals around it- his right was 80% closed.
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Hey that was Mel's too!

Woo!

Great news.

That list of centers involved now is awesome too.

Soon the global evidence will be too overwhelming to ignore.

Long live the intertubes!

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What is this thing that pinches the IJV in the image?

radeck wrote:What is this thing that pinches the IJV in the image?

I dunno, rad. Ask Dr. D tomorrow. I've been wondering if the pinching is internal, due to a congenital venous malformation....this is what Zamboni states OR... if it could be external due to the cartoid sheath-

Carotid Sheath Space: Potential Cavity within the carotid sheath which extends into the mediastinum. Contains the:

Common and internal carotid arteries
Internal Jugular vein
Vagus nerve (CN X)
Deep cervical lymph nodes
Carotid sinus nerve
Sympathetic fibers
Sheath is extremely strong which prevents easy compression. Therefore a problem in the carotid sheath can crush the internal jugular vein and vagus nerve

http://iris3.med.tufts.edu/headneck/spaces.htm

Every time I see this stuff I am overcome with emotion. Thank you so much for posting this, and for all your work!

amaaaaaaaaaaaaaazing!

Great Cheer!

They just published the case on Prof. Haacke's side:

http://www.ms-mri.com/case.php?filesent=3.pdf&#scroll

It shows that the jugular vein of riader (that's the nick-name of the german patient) is blocked by the carotid artery.

If you are able to understand german here is the thread in the german forum: http://csvi-ms.net/forum/viewtopic.php?f=2&t=163

Ana wrote:They just published the case on Prof. Haacke's side:

http://www.ms-mri.com/case.php?filesent=3.pdf&#scroll

It shows that the jugular vein of riader (that's the nick-name of the german patient) is blocked by the carotid artery.

If you are able to understand german here is the thread in the german forum: http://csvi-ms.net/forum/viewtopic.php?f=2&t=163

Thanks Ana! The interesting thing is that this is alot like May Thurner syndrome in the legs, where the right iliac artery pushes against the left iliac vein and crimps it. This is what Dr. Simka first suggested to me when he studied the vein interior of MS patients, and Dr. Dake used to base his stent intervention (stents are the protocol in May Thurner) The artery is stronger than the vein, it can't compete. Will be interesting to see how many MSers have this particular condition-
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