Study: Oxidative Stress and Neurodegenerative Diseases
Posted: Mon Jan 11, 2010 6:32 am
Hi all.
I have found this very interesting study and I would like to share it with you. Not very related to CCSVI itself, but it discusses some ways the neural cells die, including Fe poisoning and Fe induced inflammation.
Here is the full text:
link
If somebody could upload it somewhere, because I don't know how long I could keep it here for.
I have found this very interesting study and I would like to share it with you. Not very related to CCSVI itself, but it discusses some ways the neural cells die, including Fe poisoning and Fe induced inflammation.
Here is the full text:
link
If somebody could upload it somewhere, because I don't know how long I could keep it here for.
sou(r)Bayani Uttara Ajay V. Singh, Paolo Zamboni and R.T. Mahajan
Abstract: Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body
plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants,
overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading
to neuro-degeneration. Neural cells suffer functional or sensory loss in neurodegenerative diseases. Apart from several
other environmental or genetic factors, oxidative stress (OS) leading to free radical attack on neural cells contributes calamitous
role to neuro-degeneration. Though, oxygen is imperative for life, imbalanced metabolism and excess reactive
oxygen species (ROS) generation end into a range of disorders such as Alzheimer’s disease, Parkinson’s disease, aging
and many other neural disorders. Toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue
damage and subsequent cellular apoptosis. Antioxidants are now being looked upon as persuasive therapeutic against solemn
neuronal loss, as they have capability to combat by neutralizing free radicals. Diet is major source of antioxidants, as
well as medicinal herbs are catching attention to be commercial source of antioxidants at present. Recognition of upstream
and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal
damage as well as free radical scavenging. Antioxidants have a wide scope to sequester metal ions involved in neuronal
plaque formation to prevent oxidative stress. In addition, antioxidant therapy is vital in scavenging free radicals and ROS
preventing neuronal degeneration in post-oxidative stress scenario.