MS B-cells secretory products are toxic
Posted: Sun May 14, 2017 9:16 am
B-cells again pointed as the culprit in MS.
Of course this does not exclude any other research way (clamidia? ccsvi? iron? guts?). All can be connected. But now it is absolutely clear that B-cells are a big piece of the puzzle.
B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro
http://www.jni-journal.com/article/S016 ... text?cc=y=
Abstract
B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of relapsing remitting MS (RRMS) patients, but not normal controls (NC), were cytotoxic to rat oligodendrocytes (OL). We now show that RRMS blood B cells, not stimulated in vitro, secrete factor/s toxic to rat and human neurons. Cytotoxicity is independent of Ig and multiple cytokines, not complement-mediated, and involves apoptosis. The factor/s have an apparent mw of >300 kDa. B cells could contribute to damage within the central nervous system by secreting molecules toxic to OL and neurons.
Of course this does not exclude any other research way (clamidia? ccsvi? iron? guts?). All can be connected. But now it is absolutely clear that B-cells are a big piece of the puzzle.
B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro
http://www.jni-journal.com/article/S016 ... text?cc=y=
Abstract
B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of relapsing remitting MS (RRMS) patients, but not normal controls (NC), were cytotoxic to rat oligodendrocytes (OL). We now show that RRMS blood B cells, not stimulated in vitro, secrete factor/s toxic to rat and human neurons. Cytotoxicity is independent of Ig and multiple cytokines, not complement-mediated, and involves apoptosis. The factor/s have an apparent mw of >300 kDa. B cells could contribute to damage within the central nervous system by secreting molecules toxic to OL and neurons.