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Repeated exposure to environmental ozone causes a chronic state of oxidative stress. This state is present in chronic degenerative diseases and induces a loss of control of the inflammatory response. Redox system dysfunction and failures in control of inflammatory responses are involved in a vicious circle that maintains and increases the degenerative process. The intestine also responds to secondary reactive species formed by exposure to ozone doses, generating noxious stimuli that increase degenerative damage...
2024 Feb 20 Exposure to Ozone Downregulates Bcl-2 and Increases Executing Caspases-3 and -8 in the Hippocampus, Frontal Cortex, and Cerebellum of Rats https://pubmed.ncbi.nlm.nih.gov/38516464/
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MS
2020 JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response https://www.sciencedirect.com/science/a ... 1619304619 ..p-Bcl-2 levels are significantly decreased in RRMS patients during relapses
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Published: December 1999 Involvement of caspases in cytotoxic cytokine-mediated oligodendrocyte cell death https://link.springer.com/article/10.1007/BF01288207
.. Our results suggest that the inhibition of caspases may be a novel approach to treat multiple sclerosis.
2024 Mar 23
Department of Molecular Cell Biology and Immunology, UMC Location Vrije Universiteit Amsterdam, The Netherlands Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/38521959/
Conclusion: Collectively, our findings suggest a novel role for endothelial TRPV4 in MS, in which enhanced expression contributes to MS pathogenesis by driving BBB dysfunction and immune cell migration.
Re: Tropospheric ozone
Posted: Mon Mar 25, 2024 6:55 am
by Petr75
Progway 01/2023
Re: Tropospheric ozone
Posted: Mon Mar 25, 2024 7:10 am
by Petr75
O3
2024 Mar 7
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, and Peking University Institute of Environmental Medicine, Beijing, China Low-level ambient ozone exposure associated with neutrophil extracellular traps and pro-atherothrombotic biomarkers in healthy adults https://pubmed.ncbi.nlm.nih.gov/38523002/
Conclusions: Ambient O3 exposure was associated with significant increases in NETs and pro-atherothrombotic potential, even at exposure levels well below current air quality guidelines of the World Health Organization.
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Highlights
•Neutrophil-lymphocyte ratio was significantly higher in multiple sclerosis (MS) patients compared to controls.
Re: Tropospheric ozone
Posted: Sun Apr 07, 2024 10:18 pm
by Petr75
O3
2023 Mar 29 Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific https://pubmed.ncbi.nlm.nih.gov/37047376/
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2024 Feb 27 Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: An ultrahigh field MRI study https://pubmed.ncbi.nlm.nih.gov/38582026/
Background: Previous studies have shown that thalamic and hippocampal neurodegeneration is associated with clinical decline in Multiple Sclerosis (MS). However, contributions of the specific thalamic nuclei and hippocampal subfields require further examination. ...
Conclusions: Elevated maternal exposure to O3 during pregnancy, particularly in the perinatal period, is linked to an increased risk of fetal CTDs. Further longitudinal analyses are needed to validate these results.
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2024 Mar 30 Long-term ambient ozone exposure and incident cardiovascular diseases: National cohort evidence in China https://pubmed.ncbi.nlm.nih.gov/38636234/
Several studies have suggested an association between MS and heart disease, and research is ongoing to understand their relationship.2
Elevated triglyceride
and LDL cholesterol (low-density lipoprotein, considered "bad") levels have been associated with worse MS symptoms and more brain imaging abnormalities.
2015 Mar 11 Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/25879961/
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2024 Mar Disease-associated astrocyte epigenetic memory promotes CNS pathology https://pubmed.ncbi.nlm.nih.gov/38509377/
.... Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1-8 (EAE)
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..Context: Ozone (O₃) exposure is associated with a disruption of iron homeostasis and increased availability of this metal which potentially contributes to an oxidative stress and biological effects.
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..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS
#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds https://multiplesclerosisnewstoday.com/ ... udy-finds/
.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.
Re: Tropospheric ozone
Posted: Tue Apr 23, 2024 9:38 am
by Petr75
Petr75 wrote: ↑Mon Jan 24, 2022 12:00 pm
18 November 2021
School of Public Health, Capital Medical University, China The association between ozone and ischemic stroke morbidity among patients with type 2 diabetes in Beijing, China https://www.sciencedirect.com/science/a ... 9721068091
2022 Jan 6
Nanshan School, Guangzhou Medical University, China Myocardial infarction and stroke risks in multiple sclerosis patients: A two-sample Mendelian randomization study https://pubmed.ncbi.nlm.nih.gov/35066269/.....
2024 Apr 4
Second Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece Prevalence and epidemiology of stroke in patients with multiple sclerosis: a systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/38573365/
..Conclusion: The findings of the present meta-analysis indicate that MS is associated with an increased risk for ischaemic and haemorrhagic stroke. Future well-designed epidemiological studies are warranted to corroborate the robustness of the present findings in the MS population.
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..Additionally, there is a need for more studies structured around the interactions of MS and DMIΙ and assessing the direction of potential causation between those two conditions.
..The risk of developing T2DM was 1.54 times higher in patients with NMOSD than in control populations matched by age, sex, hypertension, and dyslipidemia.
With the issue of ozone (O3) pollution having increasingly gained visibility and prominence in China, the Chinese government explored various policies to mitigate O3 pollution.