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Posted: Tue Aug 02, 2005 12:55 pm Post subject: Summary of the pipeline
Here's a summary I just put together for myself that I thought I'd share. I've compiled all the substances I could find on the net currently in the research pipeline as disease-modifying treatments for MS. I didn't include detailed information, I just wanted to list what is out there and where it stands (to the best of my ability). Generally, I've included the name of a substance, the brand name (if applicable) and the name of the organization testing or marketing the substance.
If anybody sees mistakes or has stuff to add, please let me know.
MS Disease-modifying Treatment Pipeline - November 2008
Joined: Feb 02, 2004 Posts: 864 Location: California, USA
Posted: Tue Aug 02, 2005 5:14 pm Post subject:
dignan, don't take this the wrong way, but I think I love you
LOL-- this is great. I hope you won't mind if we use this list in other places on the site e.g. front page-- and credited to you, of course? _________________ Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
Excellent post. The only drugs in the trial that I know of which aren't mentioned are the Neuren drugs (see my post on Neuren). One is going into Phase III trials with the US Army.
There are some neuro-protective drugs being trialled by the UK MS Society for those with SPMS - I'll find out the names.
Some on the list are bound to fall by the wayside but that should still leave some which should turn out to be better than the current treatment options.
All we need is something to stop the damage being done, protect what we have left, and initiate repair and regeneration. Hopefully, some on the list will deliver some of these.
I foresee a much more hopeful future but, as usual, it will be some time before any of these make it to market.
Not sure what Aaron is taking but declarations of love on a public website suggest that it is not on the approved list.
Joined: Feb 02, 2004 Posts: 864 Location: California, USA
Posted: Wed Aug 03, 2005 1:03 am Post subject:
hahahahha... thanks for indulging my sometimes twisted sense of humor. This list is a project we've had on the backburner for quite some time, so it was really great to have it pulled together in such a fashion.
Much LOVE, hahahha
-arron _________________ Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
Bromley,
Thanks for the pointer to Neuren. It's tough to figure out what to include from them because they make passing references to MS, but from their website info, it's not their focus at all. Because of that I just put in their NNZ-2566 as a pre-clinical candidate. I was kind of torn about including anything pre-clinical since the chances of failure are huge at that point.
You're right about Neuren. But they do mention MS as disease which their drugs might help.
I found the reference to the neuro-protective drug that I mentioned:
Quote:
we have been awarded a grant by the Multiple Sclerosis Society to carry out a clinical trial to test the neuroprotective effects of one such sodium channel blocking drug, lamotrigine, in people with the secondary progressive form of MS. We will randomize people in the trial to receive treatment either with lamotrigine or with an identical placebo (i.e. dummy) tablet for two years.
Not sure what lamotrigine is or who manufacturers it, or the status of the trial (they are looking at effectiveness rather than safety so I assume Phase II?
Quite a few Japanese pharmaceutical firms are developing MS drugs. I'll come back with some more names in due course.
What would be nice is to develop a table showing each of the drugs, and links to trial participation information, trial results, related research papers etc, key dates etc. May be those participating in trials / finished trials could feed in their views (if they know they're not on the placebo). At the end of the day this info offers hope - more effective treatments that should make our lives better / more bearable in the future. Competition should also push the drugs companies to start delivering much better treatments - for too long a small number of companies have made substantial profits from relatively ineffective treatments. I'm very suspicious that the injectibles all offer just 30% efficacy - it's time this deal was broken.
Bromley,
Thanks for the additions. I added lamotrigine (seems to be a Glaxosmithkline drug) to Phase II and the three Serono drugs you mentioned. I am not adding aspirin because I'm only including disease-modifying agents, nothing that just treats symptoms. It would be worthwhile to start a separate list with symptom-management treatments, but it's not something I'm taking on. Looking forward to seeing what else you unearth.
There are 40 substances in Phase II right now. Through the 90's, about 40% of drugs tested in Phase II moved on to Phase III trials. So using those stats that means about 16 of the current 40 substances being tested for MS would likely move on to Phase III trials.
There are 7 substances currently in Phase III trials and I assume Tysabri will either be pulled, or will be back on the market by early next year. The remaining 6 substances in Phase III will be there until AT LEAST the end of 2007.
So, it's quite possible that in 2008, there will be over 20 treatments for MS that will be in Phase III trials. So many that it may actually get hard to keep up with everything in Phase III. A change I look forward to.
Thanks so much for putting this list together. I did not realize that inosine, alpha lipoic acid, EFAs, and <gasp> Vitamin D are actually going through clinical trials, at least at some stage. With all of the attention about the epidemiology of sunlight/vitamin D and MS out there, and the extensive recent publications on immunomodulatory properties of Vitamin D, it is heartening to see someone pick it up. Go Canada! There are indications that Vitamin D may protect against developing MS, but I haven't seen much research on whether it might actually help treat it. I get frustrated with the pace of the drug development, and the testing of the "alternatives" is particularly exciting because those are currently available to people if the controlled trials show some positive outcomes.
Is there information on the protocol for vitamin D study, such as dosage? I hope they are not just using the standard 400IU per day, since so much of the newer research is suggesting that is not adequate, particularly for individuals with limited sunlight exposure.
Here is all the info from that report on the vitamin D study:
Paul O’Connor, MD and Melanie Ursell, St. Michael’s Hospital, Toronto Biomedical Research – A phase 1 dose escalation study of Vitamin D3 with calcium supplementation in patients with MS
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