Summary of the pipeline

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Frank, sorry to report, but the anti V5.2/V5.3 mAb turned out to be ATM-027, from Astrazeneca, which failed. The first link is to a phase 2 study of the drug, the second link is an Astrazeneca document where they actually admit that they discontinued ATM-027 (unusual for a pharma co to admit failure).

http://www.blackwell-synergy.com/links/doi/10.1111/j.1365-2125.2004.02177.x/pdf?cookieSet=1

http://www.astrazeneca.com/sites/7/imagebank/migratedpress/RD-Pipeline-0612.pdf

DizzyDean · Family Member Joined: Jun 02, 2007 Posts: 30

First of all - great job keeping track of the pipeline.

I notice your blog does not mention 4ap as an "off label" treatment, nor does it mention fampridine, the time release version of it, which completed phase III trials recently.

http://phx.corporate-ir.net/phoenix.zhtml?c=194451&p=irol-newsArticle&ID=908496&highlight=

They did have 1 death in their trial but it occurred after the end of the monitoring period, unclear if it was related.

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Dizzy, I decided to make the list about disease-modifying therapies -ie- therapies that reduce relapses or lesions or progression etc. So things to treat symptoms haven't been covered. I think it would be good to have a separate list for symptomatic treatments though if somebody else is interested in putting one together...

Frank · Posted: Mon Aug 06, 2007 5:53 am Post subject:

Dear Dignan,

I'm going to write a article in the german wikipedia about upcoming therapy options in MS.
If you dont mind I would pretty much like to copy your comprehensive list - would this be ok?

--Frank
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Current regime: Tysabri restarted 05/2008 after LDN, ABX Wheldon Regime for 1 year, interested in T-Cell vaccination, helminth immunomodulation

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Go right ahead Frank. I'm just happy for this info to be as easy to find as possible.

Frank · Posted: Wed Aug 08, 2007 9:39 am Post subject:

Thanks Dignan.
If anyone would like to see how the article looks - here it is.

--Frank
_________________
Current regime: Tysabri restarted 05/2008 after LDN, ABX Wheldon Regime for 1 year, interested in T-Cell vaccination, helminth immunomodulation

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Wyeth's Temsirolimus was in a phase 2 trial for MS. All mention of temsirolimus for MS has been removed from Wyeth's website. Another one bites the dust.

notasperfectasyou · Posted: Mon Aug 20, 2007 2:46 pm Post subject: The NAC study in Phase 2

Thanks for this thread, it's really a great and hopeful resource!!! I'm interested in the NAC study that was discussed on the boards at: TIMS thread on NAC trial

The link below goes to the clinical trial site, which says the study has been completed. How can I find out the results?

link to completed trial

napay
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My Starting Point
Understanding MS 101: Doctor Talk and People Talk

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Napay, good question, I couldn't find any information on the trial results. It is possible they aren't ready to release them yet. Maybe the researchers would answer an email from you...

notasperfectasyou · Posted: Mon Aug 20, 2007 10:14 pm Post subject:

gwa · Family Elder Joined: Dec 02, 2005 Posts: 847

These researchers frequently have a pr person that answers emails. So if you can find an email address, chances are good that someone will contact you.

I have been successful in getting most emails answered that I have sent out over the years asking about current research.

gwa

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Since the new Rebif formulation has been approved in the EU, I'm taking it out of phase 3 and I'll note that the approved rebif is the new version in the list.

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Based on this link just posted by Bromley, I've added minocycline to phase 3. I kept it in phase 2 as well since there are ongoing phase 2 trials.

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=636

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Based on the Peptimmune website, I'm moving their drug (PI-2301) from pre-clinical to phase 1.

http://www.peptimmune.com/pipeline.asp

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

Sunphenon EGCg (Epigallocatechin-Gallate), which is found in green tea, is being tested in a phase 1/2 trial in Germany.

Clinicaltrials.gov